Voltage compartmentalization in dendritic spines in vivo.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
07 Jan 2022
07 Jan 2022
Historique:
pubmed:
12
11
2021
medline:
15
1
2022
entrez:
11
11
2021
Statut:
ppublish
Résumé
Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their function must be critical for the brain. Spines are biochemical compartments but might also electrically modify synaptic potentials. Using two-photon microscopy and a genetically encoded voltage indicator, we measured membrane potentials in spines and dendrites from pyramidal neurons in the somatosensory cortex of mice during spontaneous activity and sensory stimulation. Spines and dendrites were depolarized together during action potentials, but, during subthreshold and resting potentials, spines often experienced different voltages than parent dendrites, even activating independently. Spine voltages remained compartmentalized after two-photon optogenetic activation of individual spine heads. We conclude that spines are elementary voltage compartments. The regulation of voltage compartmentalization could be important for synaptic function and plasticity, dendritic integration, and disease states.
Identifiants
pubmed: 34762487
doi: 10.1126/science.abg0501
pmc: PMC8942082
mid: NIHMS1784714
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-86Subventions
Organisme : NEI NIH HHS
ID : R01 EY011787
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115900
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110422
Pays : United States
Organisme : NINDS NIH HHS
ID : R34 NS116740
Pays : United States
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