Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus.
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
04
10
2021
accepted:
25
10
2021
pubmed:
13
11
2021
medline:
8
4
2022
entrez:
12
11
2021
Statut:
ppublish
Résumé
Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.
Identifiants
pubmed: 34764015
pii: S1471-4906(21)00232-5
doi: 10.1016/j.it.2021.10.010
pii:
doi:
Substances chimiques
Interferon Inducers
0
Interferon Type I
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1054-1056Subventions
Organisme : NIAID NIH HHS
ID : R01 AI128901
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The author declares no conflicts of interest.