Enteropathies with villous atrophy but negative coeliac serology in adults: current issues.
celiac disease
gluten free diet
malabsorption
small intestinal biopsy
Journal
BMJ open gastroenterology
ISSN: 2054-4774
Titre abrégé: BMJ Open Gastroenterol
Pays: England
ID NLM: 101660690
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
13
09
2021
accepted:
21
10
2021
entrez:
12
11
2021
pubmed:
13
11
2021
medline:
26
4
2022
Statut:
ppublish
Résumé
The differential diagnosis and management of seronegative enteropathies is challenging due to the rarity of these conditions, the overlap of clinical and histopathological features and the current lack of an international consensus on their nomenclature. This is a narrative review providing pragmatic guide on the investigation and clinical management of seronegative enteropathies in adults based on the available literature and our clinical experience. Seronegative coeliac disease is the most frequent cause among the heterogeneous group of seronegative enteropathies and its diagnosis is confirmed by the clinical and histological response to a gluten-free diet after the exclusion of other causes of villous atrophy. Correct identification and targeted management of seronegative enteropathies is mandatory because of the variation in terms of clinical outcomes and prognosis.
Identifiants
pubmed: 34764141
pii: bmjgast-2021-000630
doi: 10.1136/bmjgast-2021-000630
pmc: PMC8587352
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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