Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 11 2021
11 11 2021
Historique:
received:
27
10
2020
accepted:
31
05
2021
entrez:
12
11
2021
pubmed:
13
11
2021
medline:
28
1
2022
Statut:
epublish
Résumé
Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exercise, to determine if a 1-week intervention is sufficient to induce brain changes. Fifteen healthy young males completed five supervised exercise training sessions over seven days. This was preceded and followed by a multi-modal magnetic resonance imaging (MRI) scan (diffusion-weighted MRI, perfusion-weighted MRI, dual-calibrated functional MRI) acquired 1 week apart, and blood sampling for BDNF. A diffusion tractography analysis showed, after exercise, a significant reduction relative to baseline in restricted fraction-an axon-specific metric-in the corpus callosum, uncinate fasciculus, and parahippocampal cingulum. A voxel-based approach found an increase in fractional anisotropy and reduction in radial diffusivity symmetrically, in voxels predominantly localised in the corpus callosum. A selective increase in hippocampal blood flow was found following exercise, with no change in vascular reactivity. BDNF levels were not altered. Thus, we demonstrate that 1 week of exercise is sufficient to induce microstructural and vascular brain changes on a group level, independent of BDNF, providing new insight into the temporal dynamics of plasticity, necessary to exploit the therapeutic potential of exercise.
Identifiants
pubmed: 34764358
doi: 10.1038/s41598-021-01630-7
pii: 10.1038/s41598-021-01630-7
pmc: PMC8586229
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22061Subventions
Organisme : Wellcome Trust
ID : 200804/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102403/Z/13/2
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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