Autocrine vitamin D signaling switches off pro-inflammatory programs of T

25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism Basic-Leucine Zipper Transcription Factors / metabolism Bronchoalveolar Lavage Fluid / cytology COVID-19 / immunology Complement C3a / immunology Complement C3b / immunology Humans Interferon-gamma / immunology Interleukin-10 / immunology JNK Mitogen-Activated Protein Kinases / metabolism Lymphocyte Activation / immunology Receptors, Calcitriol / metabolism Respiratory Distress Syndrome / immunology SARS-CoV-2 / immunology STAT3 Transcription Factor / metabolism Signal Transduction / immunology Th1 Cells / immunology Transcription, Genetic / genetics Vitamin D / metabolism

Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
01 2022
Historique:
received: 23 07 2020
accepted: 26 10 2021
pubmed: 13 11 2021
medline: 12 1 2022
entrez: 12 11 2021
Statut: ppublish

Résumé

The molecular mechanisms governing orderly shutdown and retraction of CD4

Identifiants

DOI: 10.1038/s41590-021-01080-3 PMID: 34764490 PMC: PMC7612139
pubmed: 34764490
doi: 10.1038/s41590-021-01080-3
pii: 10.1038/s41590-021-01080-3
pmc: PMC7612139
mid: EMS137571
doi:

Substances chimiques

BACH2 protein, human 0
Basic-Leucine Zipper Transcription Factors 0
IFNG protein, human 0
IL10 protein, human 0
Receptors, Calcitriol 0
STAT3 Transcription Factor 0
STAT3 protein, human 0
VDR protein, human 0
Interleukin-10 130068-27-8
Vitamin D 1406-16-2
Complement C3a 80295-42-7
Complement C3b 80295-43-8
Interferon-gamma 82115-62-6
25-Hydroxyvitamin D3 1-alpha-Hydroxylase EC 1.14.15.18
CYP27B1 protein, human EC 1.14.15.18
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

62-74

Subventions

Organisme : British Heart Foundation
ID : RG/13/12/30395
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 097261/Z/11/Z
Organisme : U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : ZIA/Hl006223
Organisme : Crohn's and Colitis Foundation (Crohn's & Colitis Foundation)
ID : CCFA no. 3765
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : DK12262401A1
Organisme : NIDDK NIH HHS
ID : R01 DK122624
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : FR 3851/2-1
Organisme : U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : ZIA/HL006193
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : ZIA/DK075149
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : ZIA/AI00117
Organisme : British Heart Foundation (BHF)
ID : RG/13/12/30395
Organisme : NIGMS NIH HHS
ID : R35 GM138283
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM138283
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : ZIA/AI001175
Organisme : U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : ZIA/Hl00622

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

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Auteurs

Daniel Chauss (D)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.

Tilo Freiwald (T)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Medic Clinic III, Department of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
ORCID: 0000-0002-4759-717X

Reuben McGregor (R)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
ORCID: 0000-0003-0684-7635

Bingyu Yan (B)

Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
ORCID: 0000-0003-4429-8200

Luopin Wang (L)

Department of Computer Science, Purdue University, West Lafayette, IN, USA.
ORCID: 0000-0001-5758-4092

Estefania Nova-Lamperti (E)

Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile.
ORCID: 0000-0002-7673-0013

Dhaneshwar Kumar (D)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Department of Computer Science, Purdue University, West Lafayette, IN, USA.

Zonghao Zhang (Z)

Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA.

Heather Teague (H)

Laboratory of Inflammation & Cardiometabolic Diseases, Cardiovascular Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.

Erin E West (EE)

Complement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.

Kevin M Vannella (KM)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Marcos J Ramos-Benitez (MJ)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Jack Bibby (J)

Complement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.

Audrey Kelly (A)

Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Amna Malik (A)

Department of Medicine, Imperial College London, London, UK.

Alexandra F Freeman (AF)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.

Daniella M Schwartz (DM)

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.

Didier Portilla (D)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Division of Nephrology and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA, USA.

Daniel S Chertow (DS)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Susan John (S)

Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
ORCID: 0000-0002-5620-1982

Paul Lavender (P)

Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Claudia Kemper (C)

Complement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.
Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
ORCID: 0000-0003-4196-1417

Giovanna Lombardi (G)

Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
ORCID: 0000-0003-4496-3215

Nehal N Mehta (NN)

Laboratory of Inflammation & Cardiometabolic Diseases, Cardiovascular Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.

Nichola Cooper (N)

Department of Medicine, Imperial College London, London, UK.

Michail S Lionakis (MS)

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-4994-9500

Arian Laurence (A)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Majid Kazemian (M)

Department of Biochemistry, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.
Department of Computer Science, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.
ORCID: 0000-0001-7080-8820

Behdad Afzali (B)

Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.
ORCID: 0000-0003-2968-1156

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › 25-Hydroxyvitamine D3 1-alpha-hydroxylase › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C3 › Complément C3a › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C3 › Complément C3b › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur calcitriol › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Autocrine vitamin D signaling switches off...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Autocrine vitamin D signaling switches off...