State-of-the-Art of Monoclonal Antibodies for the Treatment of Gastric Cancer.
Claudine 18.2 inhibitors
FGFR inhibitors
HER2-inhibitors
gastric cancer
precision oncology
Journal
Biologics : targets & therapy
ISSN: 1177-5475
Titre abrégé: Biologics
Pays: New Zealand
ID NLM: 101321511
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
05
2021
accepted:
05
10
2021
entrez:
12
11
2021
pubmed:
13
11
2021
medline:
13
11
2021
Statut:
epublish
Résumé
Gastric cancer (GC) is a complex and heterogeneous disease with poor prognosis and limited available treatment options. During recent years, several molecular stratifications have been proposed to optimize the overall treatment strategy for GC patients. Breakthroughs in cancer biology and in molecular profiling through DNA and RNA sequencing are now opening novel landscapes, leading to the personalization of molecular matched therapy. In particular, therapies against HER2, Claudine 18.2, Fibroblast Growth Factor Receptors (FGFR), and other molecular alterations could significantly improve survival outcomes in the advance phase of the disease. Furthermore, immunotherapy with checkpoint inhibitors also represents a promising option in a selected population. Hoping that precision oncology will enter soon in clinical practice, our review describes the state of the art of many novel pathways and the current evidence supporting the use of monoclonal antibodies implicated in GC treatment.
Identifiants
pubmed: 34764633
doi: 10.2147/BTT.S290323
pii: 290323
pmc: PMC8572727
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
451-462Informations de copyright
© 2021 Basile et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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