Remote Ischemic Conditioning in Ischemic Stroke and Myocardial Infarction: Similarities and Differences.
cardiac protection
ischemic stroke
myocardial infarction
neuroprotection
remote ischemic conditioning (RIC)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
05
2021
accepted:
23
09
2021
entrez:
12
11
2021
pubmed:
13
11
2021
medline:
13
11
2021
Statut:
epublish
Résumé
Acute myocardial infarction and ischemic stroke are leading causes of morbidity and mortality worldwide. Although reperfusion therapies have greatly improved the outcomes of patients with these conditions, many patients die or are severely disabled despite complete reperfusion. It is therefore important to identify interventions that can prevent progression to ischemic necrosis and limit ischemia-reperfusion injury. A possible strategy is ischemic conditioning, which consists of inducing ischemia - either in the ischemic organ or in another body site [i.e., remote ischemic conditioning (RIC), e.g., by inflating a cuff around the patient's arm or leg]. The effects of ischemic conditioning have been studied, alone or in combination with revascularization techniques. Based on the timing (before, during, or after ischemia), RIC is classified as pre-, per-/peri-, or post-conditioning, respectively. In this review, we first highlight some pathophysiological and clinical similarities and differences between cardiac and cerebral ischemia. We report evidence that RIC reduces circulating biomarkers of myocardial necrosis, infarct size, and edema, although this effect appears not to translate into a better prognosis. We then review cutting-edge applications of RIC for the treatment of ischemic stroke. We also highlight that, although RIC is a safe procedure that can easily be implemented in hospital and pre-hospital settings, its efficacy in patients with ischemic stroke remains to be proven. We then discuss possible methodological issues of previous studies. We finish by highlighting some perspectives for future research, aimed at increasing the efficacy of ischemic conditioning for improving tissue protection and clinical outcomes, and stratifying myocardial infarction and brain ischemia patients to enhance treatment feasibility.
Identifiants
pubmed: 34764925
doi: 10.3389/fneur.2021.716316
pmc: PMC8576053
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
716316Informations de copyright
Copyright © 2021 Saccaro, Aimo, Emdin and Pico.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuroradiol J. 2015 Apr;28(2):152-71
pubmed: 26156097
Eur J Neurol. 2021 Apr;28(4):1225-1233
pubmed: 33217147
Lancet. 2019 Oct 19;394(10207):1415-1424
pubmed: 31500849
Basic Res Cardiol. 2016 Mar;111(2):10
pubmed: 26768477
Circ Res. 2019 May 10;124(10):1482-1491
pubmed: 30929570
Nat Rev Neurol. 2018 Jun;14(6):325-337
pubmed: 29674752
J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1987-1992
pubmed: 31036341
J Stroke Cerebrovasc Dis. 2018 Apr;27(4):831-838
pubmed: 29395650
Circulation. 1986 Nov;74(5):1124-36
pubmed: 3769170
Shock. 2020 Mar;53(3):269-276
pubmed: 32045394
Basic Res Cardiol. 2018 Mar 7;113(3):14
pubmed: 29516192
BMC Neurol. 2020 Jul 2;20(1):266
pubmed: 32615939
JAMA. 2020 Oct 13;324(14):1386
pubmed: 33048138
Cardiovasc Drugs Ther. 2020 Jun 30;:
pubmed: 32607820
J Cell Physiol. 2019 Aug;234(8):12637-12645
pubmed: 30536714
Stroke. 2004 Mar;35(3):616-21
pubmed: 14963288
Lancet. 2019 Oct 19;394(10207):1389-1390
pubmed: 31500850
Brain Res. 2011 Apr 22;1386:184-90
pubmed: 21338588
J Am Coll Cardiol. 2009 Jan 27;53(4):309-15
pubmed: 19161878
Cell Mol Neurobiol. 2017 Jan;37(1):169-182
pubmed: 26971954
Stroke. 2013 Apr;44(4):1191-7
pubmed: 23339961
Clin Neurol Neurosurg. 2013 Oct;115(10):2124-9
pubmed: 23958050
Neurology. 2012 Oct 30;79(18):1853-61
pubmed: 23035060
Brain Stimul. 2012 Jan;5(1):1-10
pubmed: 22037134
Eur Heart J. 2015 Nov 21;36(44):3049-57
pubmed: 26385956
J Am Coll Cardiol. 2015 Jun 30;65(25):2764-5
pubmed: 26112203
JAMA. 2016 Sep 27;316(12):1279-88
pubmed: 27673305
Front Neurol. 2018 Feb 06;9:40
pubmed: 29467715
Neuroscience. 1993 Oct;56(4):921-7
pubmed: 8284044
Scand J Trauma Resusc Emerg Med. 2010 Sep 06;18:48
pubmed: 20815939
Stroke. 2009 Mar;40(3 Suppl):S111-4
pubmed: 19064810
Microsc Res Tech. 2003 Apr 15;60(6):614-32
pubmed: 12645009
Exp Physiol. 2012 Aug;97(8):908-17
pubmed: 22427438
Int J Stroke. 2015 Feb;10(2):143-52
pubmed: 25598025
Basic Res Cardiol. 2005 Sep;100(5):404-12
pubmed: 15965583
J Neurointerv Surg. 2018 Oct;10(10):925-931
pubmed: 29326379
Circulation. 2006 Jul 4;114(1):40-7
pubmed: 16801464
Chin Med J (Engl). 2018 Apr 20;131(8):956-965
pubmed: 29664057
Lancet. 2009 Oct 31;374(9700):1557-65
pubmed: 19880021
Stroke. 2003 May;34(5):1299-303
pubmed: 12677017
Lancet. 2010 Feb 27;375(9716):699-700
pubmed: 20189010
J Cereb Blood Flow Metab. 2012 May;32(5):851-9
pubmed: 22274742
Heart. 2007 Jun;93(6):749-52
pubmed: 17449499
Prehosp Emerg Care. 2016;20(1):82-9
pubmed: 26270795
JACC Cardiovasc Interv. 2015 Jan;8(1 Pt B):178-188
pubmed: 25240548
J Cardiovasc Med (Hagerstown). 2012 Nov;13(11):667-74
pubmed: 23114270
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):659-60
pubmed: 15026523
Eur Heart J Cardiovasc Imaging. 2013 Dec;14(12):1150-8
pubmed: 23764484
Ann Clin Transl Neurol. 2018 Jun 06;5(7):850-856
pubmed: 30009202
Stroke. 2017 May;48(5):1412-1415
pubmed: 28265014
Stroke. 2012 Oct;43(10):2794-9
pubmed: 22910893
Basic Res Cardiol. 2018 Jun 1;113(4):25
pubmed: 29858664
J Clin Invest. 2007 Feb;117(2):289-96
pubmed: 17273548
Curr Opin Neurol. 2015 Feb;28(1):4-9
pubmed: 25490196
JAMA Neurol. 2020 Jun 1;77(6):725-734
pubmed: 32227157
Circ Res. 2019 Mar;124(5):769-778
pubmed: 30602360
Eur Heart J. 2014 Jan;35(3):168-75
pubmed: 24031025
Nat Rev Neurol. 2015 Dec;11(12):698-710
pubmed: 26585977
Exp Brain Res. 2021 Aug;239(8):2561-2567
pubmed: 34185099
Neurotherapeutics. 2015 Jul;12(3):667-77
pubmed: 25956401
Basic Res Cardiol. 2014 Mar;109(2):400
pubmed: 24407359
Trials. 2019 Mar 15;20(1):167
pubmed: 30876432
Compr Physiol. 2015 Sep 20;5(4):1841-75
pubmed: 26426469
Interv Neurol. 2013 Sep;1(3-4):185-99
pubmed: 25187778
Acta Cardiol. 2016;71(5):596-603
pubmed: 27695018
JACC Cardiovasc Interv. 2013 Oct;6(10):1055-63
pubmed: 24156966
Cardiovasc Res. 2012 Sep 1;95(4):487-94
pubmed: 22739118
Sci Rep. 2020 Oct 9;10(1):16874
pubmed: 33037284
Open Heart. 2017 May 22;4(1):e000569
pubmed: 28861274
Neurology. 2012 Sep 25;79(13 Suppl 1):S52-7
pubmed: 23008413
J Neuropathol Exp Neurol. 2001 Jan;60(1):85-93
pubmed: 11202178
Eur Heart J. 2014 Jan;35(3):147-55
pubmed: 24096325
Lancet. 2010 Feb 27;375(9716):727-34
pubmed: 20189026
Stroke. 1999 Sep;30(9):1851-4
pubmed: 10471435
Ann Clin Transl Neurol. 2020 Jun;7(6):972-979
pubmed: 32472628
Lancet. 2007 Aug 18;370(9587):575-9
pubmed: 17707752
Brain Res Bull. 2017 May;131:39-46
pubmed: 28284901
Ann Clin Transl Neurol. 2019 Jan 16;6(2):364-372
pubmed: 30847368
Neurology. 2020 Dec 15;95(24):e3355-e3363
pubmed: 33028663
World Neurosurg. 2018 Aug;116:5-13
pubmed: 29733986
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
Neurobiol Dis. 2013 Jun;54:105-14
pubmed: 23454199
Lancet. 1997 May 24;349(9064):1498-504
pubmed: 9167458
World J Cardiol. 2015 Oct 26;7(10):621-32
pubmed: 26516416
Neuropsychiatr Dis Treat. 2020 Jan 23;16:283-299
pubmed: 32021218
Circulation. 2017 Apr 4;135(14):1325-1335
pubmed: 28174194
Stroke. 2014 Jan;45(1):159-67
pubmed: 24203849
Lancet. 2020 Oct 17;396(10258):1204-1222
pubmed: 33069326
Brain Res. 2012 Jun 12;1459:81-90
pubmed: 22560096