Stability of ex vivo coagulation factor activity in never-frozen and thawed refrigerated canine plasma stored for 42 days.
ACL TOP 300
blood bank
clotting
fibrinogen
hemostasis
transfusion
Journal
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
ISSN: 1476-4431
Titre abrégé: J Vet Emerg Crit Care (San Antonio)
Pays: United States
ID NLM: 101152804
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
05
07
2020
received:
19
05
2020
accepted:
23
08
2020
pubmed:
13
11
2021
medline:
16
3
2022
entrez:
12
11
2021
Statut:
ppublish
Résumé
The primary objective of this study was to document coagulation factor activity in canine "NEVER-FROZEN" and "THAWED" refrigerated plasma for the purposes of defining recommended expiration dates. We hypothesized that NEVER-FROZEN and THAWED refrigerated plasma would maintain >50% activity of coagulation factors V (FV), VII (FVII), VIII (FVIII), IX (FIX), X (FX), and von Willebrand factor antigen (vWF) and a concentration of fibrinogen above the lower bound of the reference interval (>0.982 g/L) for greater than 14 days but less than 42 days. Prospective laboratory-based study. University teaching hospital blood bank. Ten canine plasma units derived from healthy client-owned blood donors. Serial sampling (days 0, 1, 3, 5, 7, 10, 14, 17, 21, 24, 28, 32, 35, 39, 42) from NEVER-FROZEN and THAWED refrigerated canine plasma units was conducted for measurement of activities of FV, FVII, FVIII, FIX, FX, vWF, and fibrinogen concentrations using the ACL TOP 300. Plasma was defined as "suitable for transfusion" at a given time point if the entire 95% confidence interval for each factor was above 50% activity and above a fibrinogen concentration of 0.982 g/L. The lower bounds of the FVIII and vWF confidence intervals were above 50% up to and including day 32 for NEVER-FROZEN refrigerated plasma and day 28 for THAWED refrigerated plasma. Confidence intervals for FV, FVII, FIX, and FX remained above 50% activity at all time points. The lower bound of the fibrinogen concentration was <0.982 g/L on day 39 for NEVER-FROZEN refrigerated plasma and on day 35 for THAWED refrigerated plasma. Refrigerated canine plasma from these 10 dogs retained coagulation factor activity above the limit that we defined as suitable for transfusion for up to 32 days when NEVER-FROZEN and 28 days when THAWED. Further studies should evaluate the clinical outcomes and effects on coagulation factor activity of dogs receiving refrigerated plasma transfusions.
Substances chimiques
Blood Coagulation Factors
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-195Subventions
Organisme : Australian Companion Animal Health Foundation
ID : 022/18
Informations de copyright
© Veterinary Emergency and Critical Care Society 2021.
Références
Beer Kari Santoro, Silverstein Deborah C. Controversies in the use of fresh frozen plasma in critically ill small animal patients. Journal of Veterinary Emergency and Critical Care. 2015;25:(1):101-106. https://doi.org/10.1111/vec.12280
Snow SJ, Jutkowitz LA, Brown AJ. Retrospective study: trends in plasma transfusion at a veterinary teaching hospital: 308 patients (1996-1998 and 2006-2008). J Vet Emerg Crit Care. 2010;20(4):441-445.
Jutkowitz LA, Rozanski EA, Moreau JA, Rush JE. Massive transfusion in dogs: 15 cases (1997-2001). J Am Vet Med Assoc. 2002;220(11):1664-1669.
Grochowsky AR, Rozanski EA, Laforcade AM, et al. An ex vivo evaluation of efficacy of refrigerated canine plasma. J Vet Emerg Crit Care. 2014;24(4):388-397.
Turner MA, Rahilly LJ, O'Marra SK. Ex vivo evaluation of the efficacy of canine fresh-frozen plasma thawed using a microwave plasma defroster. J Vet Emerg Crit Care. 2018;28(6):603-607.
Torkildsen L, Bishop MA, Barr JW, Pashmakova MB. Comparison of multiple thawing techniques on thaw time and stability of hemostatic proteins in canine plasma products. J Small Anim Pract. 2018;59(10):641-645.
Matijevic N, Wang Y-W, Cotton BA, et al. Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma. J Trauma Acute Care Surg. 2013;74(1):84-91.
Miglio A, Stefanetti V, Antognoni MT, et al. Stored canine whole blood units: what is the real risk of bacterial contamination? J Vet Intern Med. 2016;30(6):1830-1837.
Kitchen AD, Barbara JAJ. Transfusion-transmitted non-viral infections. Curr Opin Infect Dis. 1994;7(4):493-498.
Guinet F, Carniel E, Leclercq A. Transfusion-transmitted Yersinia enterocolitica sepsis. Clin Infect Dis. 2011;53(6):583-591.
Hohenhaus AE, Drusin LM, Garvey MS. Serratia marcescens contamination of feline whole blood in a hospital blood bank. J Am Vet Med Assoc. 1997;210(6):794-798.
Roth VR, Arduino MJ, Nobiletti J, et al. Transfusion-related sepsis due to Serratia liquefaciens in the United States. Transfusion. 2000;40(8):931-935.
Walton JE, Hale AS, Brooks MB, et al. Coagulation factor and hemostatic protein content of canine plasma after storage of whole blood at ambient temperature. J Vet Intern Med. 2014;28(2):571-575.
Vilar P, Couto CG, Westendorf N, et al. Thromboelastographic tracings in retired racing greyhounds and in non-greyhound dogs. J Vet Intern Med. 2008;22(2):374-379.
Sharkey LC, Little KJ, Williams KD, et al. Performance characteristics of the turbidimetric ACL-TOP CTS 300 coagulation analyzer in dogs and cats. J Vet Emerg Crit Care. 2018;28(4):317-325.
nlme: linear and nonlinear mixed effects models [computer program]. Version 3.1-137. Vienna, Austria: R Foundation for Stastical Computing; 2018.
Gosselin RC, Marshall C, Dwyre DM, et al. Coagulation profile of liquid-state plasma. Transfusion. 2013;53(3):579-590.
Nichols TC, Bellinger DA, Merricks EP, et al. Porcine and canine von Willebrand factor and von Willebrand disease: hemostasis, thrombosis, and atherosclerosis studies. Thrombosis. 2010;2010:461238.
Carlebjork G, Blomback M, Pihlstedt P. Freezing of plasma and recovery of factor VIII. Transfusion. 1986;26(2):159-162.
Sward-Nilsson AM, Persson PO, Johnson U, Lethagen S. Factors influencing factor VIII activity in frozen plasma. Vox Sang. 2006;90(1):33-39.
Pashmakova MB, Barr JW, Bishop MA. Stability of hemostatic proteins in canine fresh-frozen plasma thawed with a modified commercial microwave warmer or warm water bath. Am J Vet Res. 2015;76(5):420-425.
Otto M. Staphylococcus epidermidis - the ‘accidental’ pathogen. Nat Rev Microbiol. 2009;7(8):555-567.
Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among dogs and cats. Vet Clin North Am Small Animal Pract. 2013;43(6):1349-1372.
Drinkhouse M, Brooks MB, Stefanovski D, et al. Influence of canine donor plasma hemostatic protein concentration on quality of cryoprecipitate. J Vet Intern Med. 2018;33(1):124-131.
Zhou Z, Yu F, Buchanan A, et al. Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts. PLoS One. 2014;9(1):e84810.
Conlan MG, Folsom AR, Finch A, et al. Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb Haemost. 1993;70(3):380.