The marriage of chemokines and galectins as functional heterodimers.
Cytokines
Glycoprotein
Inflammation
Lectin
Leukocytes
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
04
05
2021
accepted:
22
10
2021
revised:
05
10
2021
pubmed:
13
11
2021
medline:
15
12
2021
entrez:
12
11
2021
Statut:
ppublish
Résumé
Trafficking of leukocytes and their local activity profile are of pivotal importance for many (patho)physiological processes. Fittingly, microenvironments are complex by nature, with multiple mediators originating from diverse cell types and playing roles in an intimately regulated manner. To dissect aspects of this complexity, effectors are initially identified and structurally characterized, thus prompting familial classification and establishing foci of research activity. In this regard, chemokines present themselves as role models to illustrate the diversification and fine-tuning of inflammatory processes. This in turn discloses the interplay among chemokines, their cell receptors and cognate glycosaminoglycans, as well as their capacity to engage in new molecular interactions that form hetero-oligomers between themselves and other classes of effector molecules. The growing realization of versatility of adhesion/growth-regulatory galectins that bind to glycans and proteins and their presence at sites of inflammation led to testing the hypothesis that chemokines and galectins can interact with each other by protein-protein interactions. In this review, we present some background on chemokines and galectins, as well as experimental validation of this chemokine-galectin heterodimer concept exemplified with CXCL12 and galectin-3 as proof-of-principle, as well as sketch out some emerging perspectives in this arena.
Identifiants
pubmed: 34767039
doi: 10.1007/s00018-021-04010-6
pii: 10.1007/s00018-021-04010-6
pmc: PMC8629806
doi:
Substances chimiques
Chemokines
0
Galectins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8073-8095Subventions
Organisme : National Science Foundation
ID : BIR-961477
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1123, A2
Informations de copyright
© 2021. The Author(s).
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