Osteocytes and Weightlessness.
Bone cells
Cytokines
Lacuna-canalicular network
Osteocytes
Peri-lacunar remodeling
Weightlessness
Journal
Current osteoporosis reports
ISSN: 1544-2241
Titre abrégé: Curr Osteoporos Rep
Pays: United States
ID NLM: 101176492
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
accepted:
26
09
2021
pubmed:
13
11
2021
medline:
18
3
2022
entrez:
12
11
2021
Statut:
ppublish
Résumé
Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions or in simulated microgravity conditions models on Earth. After a brief recall of the main changes in bone mass and osteoclastic and osteoblastic activities in space-related models, this review focuses on the potential role of osteocytes in directing these changes. The role of the best-known signalling molecules is questioned, in particular in relation to osteocyte apoptosis. The mechanotransduction actors identified in spatial conditions and the problems related to fluid flow and shear stress changes, probably enhanced by the alteration in fluid flow and lack of convection during spaceflight, are recalled and discussed.
Identifiants
pubmed: 34767119
doi: 10.1007/s11914-021-00713-8
pii: 10.1007/s11914-021-00713-8
pmc: PMC8716347
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
626-636Subventions
Organisme : European Space Agency
ID : 4000128599/19/NL/PG
Organisme : Centre National d'Etudes Spatiales
ID : 4800001065
Organisme : Centre National d'Etudes Spatiales
ID : 4800000966
Informations de copyright
© 2021. The Author(s).
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