Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels.
Cancer metastasis
Cancer metastasis through the blood vessels
Cancer metastasis through the lymphatic vessels
Journal
Clinical & experimental metastasis
ISSN: 1573-7276
Titre abrégé: Clin Exp Metastasis
Pays: Netherlands
ID NLM: 8409970
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
09
06
2021
accepted:
26
08
2021
pubmed:
13
11
2021
medline:
2
4
2022
entrez:
12
11
2021
Statut:
ppublish
Résumé
Cancer metastasis is the process by which primary cancer cells invade through the lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells spread either through the lymphatic versus blood vessels or both are not well established. Two major developments have helped us to understand the process more clearly. First, the development of the sentinel lymph node (SLN) concept which is well established in melanoma and breast cancer. The SLN is the first lymph node in the draining nodal basin to receive cancer cells. Patients with a negative SLN biopsy show a significantly lower incidence of distant metastasis, suggesting that the SLN may be the major gateway for cancer metastasis in these cancer types. Second, the discovery and characterization of several biomarkers including VEGF-C, LYVE-1, Podoplanin and Prox-1 have opened new vistas in the understanding of the induction of lymphangiogenesis by cancer cells. Cancer cells must complete multiple steps to invade the lymphatic system, some of which may be enabled by the evolution of new traits during cancer progression. Thus, cancer cells may spread initially through the main gateway of the SLN, from which evolving cancer clones can invade the blood vessels to distant sites. Cancer cells may also enter the blood vessels directly, bypassing the SLN to establish distant metastases. Future studies need to pinpoint the molecules that are used by cancer cells at different stages of metastasis via different routes so that specific therapies can be targeted against these molecules, with the goal of stopping or preventing cancer metastasis.
Identifiants
pubmed: 34767139
doi: 10.1007/s10585-021-10120-z
pii: 10.1007/s10585-021-10120-z
pmc: PMC8967809
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-179Informations de copyright
© 2021. The Author(s).
Références
J Clin Invest. 2014 Mar;124(3):922-8
pubmed: 24590277
Cell. 1999 Sep 17;98(6):769-78
pubmed: 10499794
Cell. 2018 May 31;173(6):1549
pubmed: 29856958
Genome Biol. 2005;6(2):209
pubmed: 15693956
J Clin Oncol. 2010 Jun 10;28(17):2868-73
pubmed: 20458033
Cancer Res. 2001 Nov 15;61(22):8079-84
pubmed: 11719431
J Exp Med. 2002 Sep 16;196(6):713-8
pubmed: 12235205
N Engl J Med. 1991 Jan 3;324(1):1-8
pubmed: 1701519
Science. 2017 Jul 07;357(6346):55-60
pubmed: 28684519
J Exp Med. 2001 Sep 17;194(6):F37-42
pubmed: 11561002
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2140-5
pubmed: 26858460
Clin Chem. 2020 Jan 1;66(1):161-168
pubmed: 31601564
Am J Pathol. 1995 Oct;147(4):1049-56
pubmed: 7573350
Cancer Discov. 2021 Apr;11(4):858-873
pubmed: 33811121
Cancer Res. 2015 Mar 1;75(5):892-901
pubmed: 25592149
N Engl J Med. 2006 Sep 28;355(13):1307-17
pubmed: 17005948
Nat Med. 2001 Feb;7(2):192-8
pubmed: 11175850
Mol Aspects Med. 2020 Apr;72:100817
pubmed: 31563278
Nat Genet. 2020 Jul;52(7):692-700
pubmed: 32451459
Cancer Cell. 2013 May 13;23(5):573-81
pubmed: 23680145
J Cell Sci. 2005 Oct 15;118(Pt 20):4731-9
pubmed: 16188933
Carcinogenesis. 2006 Sep;27(9):1729-38
pubmed: 16597644
Cancer Sci. 2003 Sep;94(9):751-6
pubmed: 12967471
Nature. 2020 Sep;585(7823):113-118
pubmed: 32814895
APMIS. 2008 Jul-Aug;116(7-8):754-70
pubmed: 18834417
Clin Cancer Res. 2018 May 1;24(9):2214-2224
pubmed: 29203589
Cancer Res. 2002 Nov 15;62(22):6731-9
pubmed: 12438274
Mol Cancer. 2008 Mar 06;7:23
pubmed: 18325094
Virchows Arch. 2012 Feb;460(2):183-91
pubmed: 22241180
J Am Coll Surg. 2009 Mar;208(3):333-40
pubmed: 19317993
Cancer Res. 2009 Jan 1;69(1):349-57
pubmed: 19118020
Lab Invest. 1992 Sep;67(3):331-7
pubmed: 1383607
Ann Surg. 1968 Sep;168(3):337-56
pubmed: 4970947
EBioMedicine. 2020 Jun;56:102793
pubmed: 32512508
Signal Transduct Target Ther. 2020 Aug 5;5(1):145
pubmed: 32759948
Cancer Res. 2011 Feb 1;71(3):790-800
pubmed: 21245098
Dev Dyn. 2008 Jul;237(7):1901-9
pubmed: 18570254
Semin Oncol. 2002 Dec;29(6 Suppl 16):15-8
pubmed: 12516034
Nat Commun. 2020 Apr 24;11(1):1993
pubmed: 32332722
J Natl Cancer Inst. 2019 Apr 1;111(4):380-387
pubmed: 30312434
Nat Rev Cancer. 2014 Mar;14(3):159-72
pubmed: 24561443
Cancer Res. 2005 Jun 1;65(11):4739-46
pubmed: 15930292
J Clin Oncol. 1995 Jan;13(1):8-10
pubmed: 7799047
Cell Stress. 2019 May 21;3(6):165-180
pubmed: 31225512
N Engl J Med. 2005 Aug 25;353(8):793-802
pubmed: 16120859
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12396-400
pubmed: 21746894
Nat Genet. 2020 Jul;52(7):701-708
pubmed: 32424352
Cancer. 1976 Jul;38(1):187-92
pubmed: 947514
Recent Results Cancer Res. 2000;157:55-81
pubmed: 10857162
Cancer Discov. 2015 May;5(5):506-19
pubmed: 25716347
Cell Rep. 2018 Dec 26;25(13):3554-3563.e4
pubmed: 30590031
Science. 1998 Oct 30;282(5390):946-9
pubmed: 9794766
Science. 1983 Feb 25;219(4587):983-5
pubmed: 6823562
Nat Rev Cancer. 2019 Oct;19(10):553-567
pubmed: 31455893
Sci Transl Med. 2017 Sep 13;9(407):
pubmed: 28904226
Cell. 2019 Jan 10;176(1-2):98-112.e14
pubmed: 30633912
Ann Oncol. 2006 Oct;17(10):1578-85
pubmed: 16968875
Cancer Immunol Res. 2014 May;2(5):436-47
pubmed: 24795356
Mech Dev. 1993 Nov;44(1):3-16
pubmed: 7908825
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
Biomolecules. 2020 Dec 12;10(12):
pubmed: 33322749
Oncogene. 2003 May 19;22(20):3172-9
pubmed: 12789293
Lab Invest. 1966 Feb;15(2):464-78
pubmed: 5932611
EMBO Mol Med. 2020 Sep 7;12(9):e11908
pubmed: 32667137
Nature. 2019 Feb;566(7745):553-557
pubmed: 30728496
Ann Surg. 2008 Dec;248(6):949-55
pubmed: 19092339
N Engl J Med. 2017 Nov 9;377(19):1836-1846
pubmed: 29117498
Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225-34
pubmed: 19465549
Breast Cancer Res. 2019 Sep 3;21(1):101
pubmed: 31481116
N Engl J Med. 2017 Jun 8;376(23):2211-2222
pubmed: 28591523
Nat Rev Cancer. 2012 Feb 24;12(3):210-9
pubmed: 22362216
J Cancer. 2014 Mar 11;5(3):242-7
pubmed: 24665348
Microvasc Res. 2014 Jul;94:96-102
pubmed: 24944097
Am J Pathol. 2007 Apr;170(4):1178-91
pubmed: 17392158
Cell Rep. 2012 Mar 29;1(3):191-9
pubmed: 22832193
Mol Clin Oncol. 2017 Oct;7(4):515-520
pubmed: 28855985
Cancer Cell. 2007 Jun;11(6):526-38
pubmed: 17560334
Sci Transl Med. 2014 Jul 30;6(247):247ra101
pubmed: 25080476
Science. 1989 Dec 8;246(4935):1306-9
pubmed: 2479986
Cell. 2018 Apr 19;173(3):581-594.e12
pubmed: 29656895
Dev Dyn. 2002 Nov;225(3):351-7
pubmed: 12412020
Nature. 2019 Nov;575(7781):210-216
pubmed: 31645765
Sci Adv. 2018 Aug 08;4(8):eaat4758
pubmed: 30101193
Am J Pathol. 2007 Feb;170(2):774-86
pubmed: 17255343
Arch Surg. 1992 Apr;127(4):392-9
pubmed: 1558490
Cancer Res. 2015 Dec 15;75(24):5367-77
pubmed: 26573792
J Clin Invest. 2018 Apr 2;128(4):1355-1370
pubmed: 29480816
J Natl Cancer Inst. 2014 May 15;106(5):
pubmed: 24832787
J Exp Med. 2019 May 6;216(5):1091-1107
pubmed: 30975896
J Cell Biol. 1999 Feb 22;144(4):789-801
pubmed: 10037799
Cancer Immunol Res. 2013 Nov;1(5):280-4
pubmed: 24777964
Ann Surg. 2003 Oct;238(4):538-49; discussion 549-50
pubmed: 14530725
Science. 2018 Mar 23;359(6382):1403-1407
pubmed: 29567713
Cancer Res. 1965 Feb;25:75-106
pubmed: 14264062
Int J Oncol. 1999 Sep;15(3):595-9
pubmed: 10427146
Arch Surg. 2012 Nov;147(11):1047-52
pubmed: 22802006
Arch Surg. 1984 Sep;119(9):1067-72
pubmed: 6383272
Int J Biochem Cell Biol. 2001 Apr;33(4):421-6
pubmed: 11312110
Cancer. 1977 Feb;39(2):456-66
pubmed: 837331
Nat Med. 2003 Jun;9(6):669-76
pubmed: 12778165
Front Immunol. 2017 Feb 03;8:66
pubmed: 28217128
Nature. 1995 Jul 6;376(6535):62-6
pubmed: 7596435
Cell Tissue Res. 2003 Oct;314(1):85-92
pubmed: 12883994
Nat Rev Clin Oncol. 2019 Jul;16(7):409-424
pubmed: 30796368
Nat Med. 2012 Jun;18(6):883-91
pubmed: 22635005
Clin Exp Metastasis. 2022 Feb;39(1):117-137
pubmed: 33950409
Front Bioeng Biotechnol. 2018 Feb 12;6:7
pubmed: 29484295
Clin Exp Metastasis. 2012 Oct;29(7):737-46
pubmed: 22669542
PLoS Biol. 2020 Apr 6;18(4):e3000704
pubmed: 32251437
Am J Pathol. 1997 Oct;151(4):1141-52
pubmed: 9327748
Ann Surg. 1894 Nov;20(5):497-555
pubmed: 17860107
Science. 1989 Dec 8;246(4935):1309-12
pubmed: 2479987
Crit Rev Oncol Hematol. 2020 Dec;156:103112
pubmed: 33035734
J Exp Med. 2005 Apr 4;201(7):1089-99
pubmed: 15809353
Nat Rev Cancer. 2004 Jun;4(6):448-56
pubmed: 15170447
Clin Chem. 2018 Oct;64(10):1505-1512
pubmed: 30030273
Am J Pathol. 1988 Nov;133(2):419-23
pubmed: 3189515
J Clin Cell Immunol. 2014;5:
pubmed: 25580369
Am J Pathol. 2003 Jun;162(6):1951-60
pubmed: 12759251
Ann Surg. 1994 Dec;220(6):759-67
pubmed: 7986143
Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1771-7
pubmed: 12531726
Clin Exp Metastasis. 2017 Jun;34(5):345-350
pubmed: 28699042
Nature. 1995 Jul 6;376(6535):66-70
pubmed: 7596436
Ann Surg Oncol. 2019 Jul;26(7):2254-2262
pubmed: 31011906
Trends Mol Med. 2010 Sep;16(9):398-406
pubmed: 20667783