Inactivation of Jack Bean Urease by Nitidine Chloride from

Benzophenanthridines Humans Kinetics Molecular Docking Simulation Urease / metabolism Zanthoxylum / metabolism
alkaloids enzyme kinetics nitidine chloride thiol group urease inhibitor

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
24 Nov 2021
Historique:
pubmed: 13 11 2021
medline: 26 11 2021
entrez: 12 11 2021
Statut: ppublish

Résumé

Urease is a metalloenzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide, which has a negative impact on human health and agriculture. In this study, the inactivation of jack bean urease by nitidine chloride (NC) was investigated to elucidate the inhibitory effect, kinetics, and underlying mechanism of action. The results showed that NC acted as a concentration- and time-dependent inhibitor with an IC

Identifiants

DOI: 10.1021/acs.jafc.1c04801 PMID: 34767340
pubmed: 34767340
doi: 10.1021/acs.jafc.1c04801
doi:

Substances chimiques

Benzophenanthridines 0
nitidine 933301178Z
Urease EC 3.5.1.5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13772-13779

Auteurs

Qiang Lu (Q)

Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, PR China.

Daopeng Tan (D)

College of Pharmacy, Zunyi Medical University, Zunyi 563000, PR China.

Yifei Xu (Y)

Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518005, PR China.

Meigui Liu (M)

Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, PR China.

Yuqi He (Y)

College of Pharmacy, Zunyi Medical University, Zunyi 563000, PR China.

Cailan Li (C)

Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, PR China.
ORCID: 0000-0001-6630-2587

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Benzophénanthridines › Inactivation of Jack Bean Urease by Nitidine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inactivation of Jack Bean Urease by Nitidine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Inactivation of Jack Bean Urease by Nitidine...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Inactivation of Jack Bean Urease by Nitidine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Urease › Inactivation of Jack Bean Urease by Nitidine...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Zanthoxylum › Inactivation of Jack Bean Urease by Nitidine...