Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
24
11
2021
pubmed:
13
11
2021
medline:
22
12
2021
entrez:
12
11
2021
Statut:
epublish
Résumé
Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.
Identifiants
pubmed: 34767552
doi: 10.1371/journal.pbio.3001462
pii: PBIOLOGY-D-21-02409
pmc: PMC8612770
doi:
Substances chimiques
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3001462Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
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pubmed: 27549106
J Tissue Eng. 2021 Jan 28;12:2041731420988802
pubmed: 33796248
Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584
pubmed: 32636524
Biotechnol Prog. 2018 Nov;34(6):1494-1505
pubmed: 30294883
Drug Discov Today. 2020 Apr;25(4):706-717
pubmed: 32027970
Curr Opin Biotechnol. 2019 Feb;55:81-86
pubmed: 30189349