Indigofera linifolia ameliorated CCl

Animals Anti-Inflammatory Agents / pharmacology Antioxidants / pharmacology Carbon Tetrachloride / adverse effects Carbon Tetrachloride Poisoning / drug therapy Endoplasmic Reticulum Stress / drug effects Flavonoids / pharmacology Gene Expression Regulation / drug effects Glutamate-Cysteine Ligase / metabolism Indigofera Liver / drug effects NF-E2-Related Factor 2 / metabolism Plant Extracts / pharmacology Rats Rats, Sprague-Dawley
Antioxidant Cytokines ER stress Liver TNF-α

Journal

Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310

Informations de publication

Date de publication:
01 Mar 2022
Historique:
received: 12 03 2021
revised: 21 09 2021
accepted: 05 11 2021
pubmed: 13 11 2021
medline: 25 2 2022
entrez: 12 11 2021
Statut: ppublish

Résumé

Indigofera linifolia (L.f.) Retz. is used in subcontinent for liver disorders, in wounds, febrile eruption and as diuretic. The current study evaluates the protective effects of the methanol extract of Indigofera linifolia (ILM) on CCl ILM was analyzed for phytochemical classes, total phenolic (TPC) and flavonoid content (TFC) as well as multidimensional in vitro antioxidant assays. Male (Sprague Dawley) rats were dispersed into seven groups (6 rats/group) receiving 0.9% saline (1 ml/kg bw), CCl ILM extract was constituted of different phytochemical classes. Co-administration of ILM along with CCl The results suggest that active phyto-constituents of I. linifolia might be responsible for its antioxidant, anti-inflammatory and gene-regulating activities.

Identifiants

DOI: 10.1016/j.jep.2021.114826 PMID: 34767833
pubmed: 34767833
pii: S0378-8741(21)01056-4
doi: 10.1016/j.jep.2021.114826
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Antioxidants 0
Flavonoids 0
NF-E2-Related Factor 2 0
Nfe2l2 protein, rat 0
Plant Extracts 0
Carbon Tetrachloride CL2T97X0V0
Glutamate-Cysteine Ligase EC 6.3.2.2
GCLC protein, rat EC 6.3.2.2.

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114826

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Irum Naz (I)

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Institute of Biochemistry, Biotechnology and Bioinformatics, Faculty of Sciences, The Islamia University of Bahawalpur, Pakistan. Electronic address: irumnaz@bs.qau.edu.pk.

Muhammad Rashid Khan (MR)

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: mrkhanqau@yahoo.com.

Jawaid Ahmed Zai (JA)

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: jawaidzai@gmail.com.

Riffat Batool (R)

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: biochemist60@gmail.com.

Sonia Maryam (S)

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: soniamaryam786@gmail.com.

Muhammad Majid (M)

Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan. Electronic address: majidpharma808@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Tétrachloro-méthane › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Intoxication au tétrachlorure de carbone › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Stress du réticulum endoplasmique › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Glutamate-cysteine ligase › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Indigofera › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Système digestif › Foie › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Indigofera linifolia ameliorated CCl
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Indigofera linifolia ameliorated CCl