How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
COVID-19
analgesia
management
sedation
withdrawal
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Oct 2021
24 Oct 2021
Historique:
received:
02
10
2021
revised:
12
10
2021
accepted:
22
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
14
11
2021
Statut:
epublish
Résumé
COVID-19 patients suffering from severe acute respiratory distress syndrome (ARDS) require mechanical ventilation (MV) for respiratory failure. To achieve these ventilatory goals, it has been observed that COVID-19 patients in particular require high regimens and prolonged use of sedatives, analgesics and neuromuscular blocking agents (NMBA). Withdrawal from analgo-sedation may induce a "drug withdrawal syndrome" (DWS), i.e., clinical symptoms of anxiety, tremor, agitation, hallucinations and vomiting, as a result of adrenergic activation and hyperalgesia. We describe the epidemiology, mechanisms leading to this syndrome and our strategies to prevent and treat it.
Identifiants
pubmed: 34768436
pii: jcm10214917
doi: 10.3390/jcm10214917
pmc: PMC8584278
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Hum Exp Toxicol. 2013 Jan;32(1):107-10
pubmed: 23111887
Anesth Analg. 2020 Oct;131(4):e198-e200
pubmed: 32675640
Crit Care Med. 1998 Apr;26(4):676-84
pubmed: 9559604
Paediatr Anaesth. 2003 Nov;13(9):805-10
pubmed: 14617122
Acta Paediatr. 2018 Mar 23;:
pubmed: 29570859
CMAJ. 2005 Jun 21;172(13):1703-11
pubmed: 15967975
Curr Opin Crit Care. 2021 Feb 1;27(1):6-12
pubmed: 33315636
AACN Adv Crit Care. 2019 Dec 15;30(4):353-364
pubmed: 31951658
N Engl J Med. 2003 May 1;348(18):1786-95
pubmed: 12724485
Crit Care Med. 2008 Aug;36(8):2427-32
pubmed: 18596622
Crit Care Explor. 2019 Aug 09;1(8):e0035
pubmed: 32166276
Pharmacotherapy. 2020 Dec;40(12):1180-1191
pubmed: 33068459
N Engl J Med. 2019 Jan 24;380(4):365-378
pubmed: 30673555
Acta Anaesthesiol Scand. 2021 Aug;65(7):928-935
pubmed: 33728643
J Intensive Care Med. 2016 Mar;31(3):216-20
pubmed: 26025196
Crit Care. 2008;12 Suppl 3:S3
pubmed: 18495054
Cochrane Database Syst Rev. 2009 Jul 08;(3):CD002025
pubmed: 19588330
Cell Physiol Biochem. 2014;33(6):1715-32
pubmed: 24923288
Cochrane Database Syst Rev. 2016 May 03;(5):CD002024
pubmed: 27140827
Anaesthesiol Intensive Ther. 2018;50(2):160-167
pubmed: 29882581
Ann Pharmacother. 2021 May 14;:10600280211017315
pubmed: 33985368
Crit Care Explor. 2020 Nov 03;2(11):e0245
pubmed: 33163969
Intensive Care Med. 2020 Dec;46(12):2342-2356
pubmed: 33170331
Psychosomatics. 2002 May-Jun;43(3):171-4
pubmed: 12075031
Ann Intensive Care. 2017 Sep 2;7(1):88
pubmed: 28866754
Br J Anaesth. 2010 Feb;104(2):125-7
pubmed: 20086062
Crit Care Med. 2010 Aug;38(8):1674-84
pubmed: 20581667
Crit Care Explor. 2021 Mar 12;3(3):e0353
pubmed: 33786432
Intensive Care Med. 2005 Mar;31(3):380-7
pubmed: 15714323
Ann Pharmacother. 2021 Jun 2;:10600280211021925
pubmed: 34075807
Am J Drug Alcohol Abuse. 2012 May;38(3):187-99
pubmed: 22404717
Prim Care Companion CNS Disord. 2020 Jul 16;22(4):
pubmed: 32678526
Ann Pharm Fr. 2009 Nov;67(6):408-13
pubmed: 19900604
Lancet. 2020 Jun 20;395(10241):1938-1948
pubmed: 32563380
Am Surg. 2000 Apr;66(4):367-70; discussion 370-1
pubmed: 10776874
Cochrane Database Syst Rev. 2015 Jan 06;1:CD010269
pubmed: 25879090
Intensive Care Med. 2020 Apr;46(4):606-618
pubmed: 32016537
Crit Care. 2020 Jul 31;24(1):477
pubmed: 32736637