Tailored Systemic Therapy for Colorectal Cancer Liver Metastases.
colorectal cancer
molecular biomarkers
prediction
prognosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2021
29 Oct 2021
Historique:
received:
01
10
2021
revised:
27
10
2021
accepted:
27
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Liver metastases are the most common site of metastatic spread in colorectal cancer. Current treatment approaches involve effective systemic therapies in combination with surgical and/or interventional strategies. Multimodal strategies greatly improved clinical outcomes of patients with metastatic colorectal cancer over the last decades. Identification of predictive and prognostic biomarkers helped to comprehensively refine individual targeted treatment approaches and resulted in median overall survival rates of 30 months or longer. Current guidelines, thus, recommend treatment selection according to patients' performance status, tumor localization and stage as well as the tumor's molecular and genetic status. Here, we outline the latest developments in molecular decision-making for patients with upfront resectable, potentially or initially unresectable and non/never-resectable colorectal cancer liver metastases.
Identifiants
pubmed: 34769209
pii: ijms222111780
doi: 10.3390/ijms222111780
pmc: PMC8584068
pii:
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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