Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors.
blood-brain barrier
brain tumors
carbon dots
drug-delivery systems
nanocarriers
nanoparticles
theranostic
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2021
29 Oct 2021
Historique:
received:
08
09
2021
revised:
26
10
2021
accepted:
28
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Brain tumors are particularly aggressive and represent a significant cause of morbidity and mortality in adults and children, affecting the global population and being responsible for 2.6% of all cancer deaths (as well as 30% of those in children and 20% in young adults). The blood-brain barrier (BBB) excludes almost 100% of the drugs targeting brain neoplasms, representing one of the most significant challenges to current brain cancer therapy. In the last decades, carbon dots have increasingly played the role of drug delivery systems with theranostic applications against cancer, thanks to their bright photoluminescence, solubility in bodily fluids, chemical stability, and biocompatibility. After a summary outlining brain tumors and the current drug delivery strategies devised in their therapeutic management, this review explores the most recent literature about the advances and open challenges in the employment of carbon dots as both diagnostic and therapeutic agents in the treatment of brain cancers, together with the strategies devised to allow them to cross the BBB effectively.
Identifiants
pubmed: 34769212
pii: ijms222111783
doi: 10.3390/ijms222111783
pmc: PMC8583729
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Carbon
7440-44-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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