A Patent Review on the Therapeutic Application of Monoclonal Antibodies in COVID-19.
COVID-19
innovation
monoclonal antibodies
patent reviews
therapeutic application
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Nov 2021
04 Nov 2021
Historique:
received:
11
09
2021
revised:
24
10
2021
accepted:
02
11
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains spike proteins that assist the virus in entering host cells. In the absence of a specific intervention, efforts are afoot throughout the world to find an effective treatment for SARS-CoV-2. Through innovative techniques, monoclonal antibodies (MAbs) are being designed and developed to block a particular pathway of SARS-CoV-2 infection. More than 100 patent applications describing the development of MAbs and their application against SARS-CoV-2 have been registered. Most of them target the receptor binding protein so that the interaction between virus and host cell can be prevented. A few monoclonal antibodies are also being patented for the diagnosis of SARS-CoV-2. Some of them, like Regeneron
Identifiants
pubmed: 34769383
pii: ijms222111953
doi: 10.3390/ijms222111953
pmc: PMC8584575
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Coronavirus M Proteins
0
Spike Glycoprotein, Coronavirus
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Sci Rep. 2021 Jul 30;11(1):15729
pubmed: 34330988
Nat Rev Drug Discov. 2010 Apr;9(4):325-38
pubmed: 20305665
Lancet Respir Med. 2021 May;9(5):511-521
pubmed: 33676589
Expert Opin Ther Pat. 2013 Oct;23(10):1337-48
pubmed: 23905913
MAbs. 2010 May-Jun;2(3):256-65
pubmed: 20400861
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
MAbs. 2014 Mar-Apr;6(2):422-36
pubmed: 24492301
Emerg Microbes Infect. 2020 Dec;9(1):382-385
pubmed: 32065055
J Immunol Methods. 2011 Oct 28;373(1-2):79-88
pubmed: 21856306
Vaccines (Basel). 2021 May 26;9(6):
pubmed: 34073559
JAMA. 2021 Mar 9;325(10):1015
pubmed: 33544136
Antiviral Res. 2017 May;141:101-106
pubmed: 28216367
Nature. 1975 Aug 7;256(5517):495-7
pubmed: 1172191
MAbs. 2018 Oct;10(7):1111-1130
pubmed: 30130439
BMC Med. 2013 Jan 04;11:4
pubmed: 23289632
Biotechnol Lett. 2016 Oct;38(10):1655-64
pubmed: 27334710
J Biomed Sci. 2020 Jan 2;27(1):1
pubmed: 31894001
J Biomed Sci. 2016 Jan 19;23:8
pubmed: 26786672
Int J Cancer. 2005 Aug 20;116(2):304-13
pubmed: 15800913
ACS Cent Sci. 2020 Mar 25;6(3):315-331
pubmed: 32226821
Br J Clin Pharmacol. 2008 Jul;66(1):6-19
pubmed: 18503606
Sci Rep. 2019 Apr 15;9(1):6088
pubmed: 30988390
Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18
pubmed: 32134278
J Virol. 2005 Feb;79(3):1635-44
pubmed: 15650189
Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149
pubmed: 32747721
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Drug Discov Today. 2006 Jan;11(1-2):81-8
pubmed: 16478695
Sci Transl Med. 2017 Nov 1;9(414):
pubmed: 29093180
Nat Rev Drug Discov. 2006 Mar;5(3):191-5
pubmed: 16518372
Nat Med. 2003 Mar;9(3):269-77
pubmed: 12612576
Appl Microbiol Biotechnol. 2016 Apr;100(8):3451-61
pubmed: 26936774
N Engl J Med. 2020 Dec 3;383(23):2255-2273
pubmed: 33264547
Methods. 2005 May;36(1):69-83
pubmed: 15848076
Science. 2020 May 8;368(6491):630-633
pubmed: 32245784
Semin Immunol. 2020 Aug;50:101427
pubmed: 33277154
Crit Rev Biotechnol. 2016;36(2):276-89
pubmed: 25394539
Ann Rheum Dis. 2013 Apr;72(4):517-24
pubmed: 22562972
N Engl J Med. 2018 Apr 19;378(16):1469-1472
pubmed: 29513615
Methods Mol Biol. 2014;1060:9-36
pubmed: 24037834
Cell Rep. 2020 Jul 21;32(3):107918
pubmed: 32668215
Blood. 2012 Jun 14;119(24):5640-9
pubmed: 22535666
Cell Mol Immunol. 2020 Jun;17(6):647-649
pubmed: 32313207
MAbs. 2014;6(6):1402-14
pubmed: 25484049
Science. 2020 Jun 12;368(6496):1274-1278
pubmed: 32404477
Expert Opin Pharmacother. 2019 Dec;20(18):2295-2303
pubmed: 31670984
Lancet Neurol. 2017 Jun;16(6):425-434
pubmed: 28460892
Science. 2013 Sep 13;341(6151):1192-8
pubmed: 24031011
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
World J Clin Cases. 2020 Oct 6;8(19):4280-4285
pubmed: 33083387
J Infect Public Health. 2020 Sep;13(9):1187-1195
pubmed: 32773212
Healthcare (Basel). 2021 Jul 24;9(8):
pubmed: 34442068
Atherosclerosis. 2013 May;228(1):18-28
pubmed: 23466067
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
BMC Biotechnol. 2013 Jul 05;13:55
pubmed: 23826749
Virology. 2005 Apr 10;334(2):160-5
pubmed: 15780866
Ann Rheum Dis. 2020 Oct;79(10):1277-1285
pubmed: 32620597
Mol Immunol. 2016 Sep;77:113-25
pubmed: 27497190
EMBO J. 2020 Sep 15;39(18):e106275
pubmed: 32845033
Biomed Pharmacother. 2020 Sep;129:110337
pubmed: 32534226
Curr Opin Immunol. 1993 Apr;5(2):278-81
pubmed: 8507406
JAMA. 2020 May 12;323(18):1824-1836
pubmed: 32282022
MAbs. 2015;7(1):9-14
pubmed: 25529996
Drugs. 1998 Oct;56(4):629-65
pubmed: 9806109
BMJ. 2020 Nov 11;371:m4362
pubmed: 33177042
Int J Soc Psychiatry. 2020 Jun;66(4):317-320
pubmed: 32233719
J Virol Methods. 2019 Oct;272:113690
pubmed: 31283959
Clin J Am Soc Nephrol. 2016 Jan 7;11(1):137-54
pubmed: 26700440
Int Immunopharmacol. 2020 Nov;88:106924
pubmed: 32877828
Virology. 2007 Apr 25;361(1):93-102
pubmed: 17161858
Biotechnol Prog. 2004 May-Jun;20(3):639-54
pubmed: 15176864
World J Hepatol. 2015 Oct 8;7(22):2369-83
pubmed: 26464752
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Oncogene. 2003 Dec 8;22(56):9097-106
pubmed: 14663488
Methods Mol Biol. 2009;525:1-27, xiii
pubmed: 19252861
PLoS Pathog. 2012;8(8):e1002859
pubmed: 22876187
Nat Rev Drug Discov. 2019 Aug;18(8):585-608
pubmed: 31175342
Blood. 2009 Nov 12;114(20):4494-502
pubmed: 19667400