Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).

Consensus Humans Hypersensitivity Italy / epidemiology Multiple Chemical Sensitivity / diagnosis Solvents
chemical intolerance environmental exposure multiple chemical sensitivity (MCS) neurogenic inflammation threshold limit value

Journal

International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455

Informations de publication

Date de publication:
27 10 2021
Historique:
received: 25 08 2021
revised: 15 10 2021
accepted: 19 10 2021
entrez: 13 11 2021
pubmed: 14 11 2021
medline: 23 11 2021
Statut: epublish

Résumé

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

Identifiants

DOI: 10.3390/ijerph182111294 PMID: 34769816 PMC: PMC8582949
pubmed: 34769816
pii: ijerph182111294
doi: 10.3390/ijerph182111294
pmc: PMC8582949
pii:
doi:

Substances chimiques

Solvents 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Références

Int J Hyg Environ Health. 2008 Oct;211(5-6):658-81
pubmed: 18502687
Am J Ind Med. 1988;13(4):463-72
pubmed: 3364424
Int Arch Occup Environ Health. 2017 Feb;90(2):189-196
pubmed: 27838888
PLoS One. 2020 Sep 16;15(9):e0238296
pubmed: 32936802
Scand J Public Health. 2009 Aug;37(6):621-6
pubmed: 19411319
Clin Toxicol (Phila). 2014 Apr;52(4):444
pubmed: 24645903
Electroencephalogr Clin Neurophysiol. 1979 Oct;47(4):492-8
pubmed: 89953
ISRN Nurs. 2011;2011:838930
pubmed: 22007328
Arch Environ Health. 1992 Jan-Feb;47(1):88-91
pubmed: 1540010
Ann Allergy. 1976 Aug;37(2):101-9
pubmed: 970676
Hum Brain Mapp. 2007 Mar;28(3):172-82
pubmed: 16767766
Prev Med Rep. 2019 Mar 29;14:100856
pubmed: 31193443
Dermatol Ther. 2021 Mar;34(2):e14823
pubmed: 33527560
Toxicol Appl Pharmacol. 2010 Nov 1;248(3):285-92
pubmed: 20430047
PLoS One. 2013 Aug 13;8(8):e73708
pubmed: 23967348
Clin Ther. 2018 Jun;40(6):889-893
pubmed: 29861191
Semin Arthritis Rheum. 2008 Jun;37(6):339-52
pubmed: 18191990
Noise Health. 2012 Sep-Oct;14(60):215-23
pubmed: 23117535
Neurotoxicol Teratol. 1994 Sep-Oct;16(5):489-97
pubmed: 7845332
Int J Hyg Environ Health. 2008 Oct;211(5-6):690-7
pubmed: 18403259
J Vestib Res. 2016;26(5-6):459-468
pubmed: 28262643
Ann Allergy. 1961 Jul;19:779-99 contd
pubmed: 13739469
Environ Res. 1995 Aug;70(2):84-97
pubmed: 8674484
Toxicol Rev. 2003;22(4):235-46
pubmed: 15189046
Int J Hyg Environ Health. 2010 Mar;213(2):131-9
pubmed: 20185366
Arch Environ Occup Health. 2006 Nov-Dec;61(6):285-7
pubmed: 17967752
Arch Environ Health. 1993 Sep-Oct;48(5):315-27
pubmed: 8215596
Contact Dermatitis. 2019 Jul;81(1):79
pubmed: 30843222
Environ Health Perspect. 2003 Sep;111(12):1461-4
pubmed: 12948884
Respir Physiol Neurobiol. 2013 Jun 1;187(1):128-34
pubmed: 23485801
Arch Environ Health. 1998 Sep-Oct;53(5):347-53
pubmed: 9766480
Arch Environ Health. 1993 Jan-Feb;48(1):6-13
pubmed: 7680851
Ann N Y Acad Sci. 2001 Mar;933:130-41
pubmed: 12000016
Ann Allergy. 1973 Mar;31(3):126-33
pubmed: 4688622
Brain Topogr. 2016 Mar;29(2):243-52
pubmed: 26438099
Environ Health Perspect. 1997 Mar;105 Suppl 2:417-36
pubmed: 9167975
Ann Allergy. 1977 Apr;38(4):245-51
pubmed: 322552
Addiction. 2001 Jan;96(1):115-37
pubmed: 11177524
Am J Hematol. 2019 Mar;94(3):363-377
pubmed: 30536695
Occup Med. 2000 Jul-Sep;15(3):557-70
pubmed: 10903550
Rev Environ Health. 2015;30(4):251-71
pubmed: 26613326
Environ Health Perspect. 2003 Sep;111(12):1498-504
pubmed: 12948890
J Allergy Clin Immunol. 2006 Sep;118(3):763; author reply 767-8
pubmed: 16950304
Occup Med (Lond). 2004 Sep;54(6):408-18
pubmed: 15347780
Arch Environ Occup Health. 2021;76(3):145-151
pubmed: 32544007
Toxicol Ind Health. 1992 Jul-Aug;8(4):215-9
pubmed: 1412488
Environ Health Prev Med. 2019 Oct 22;24(1):61
pubmed: 31640568
Saf Health Work. 2020 Jun;11(2):173-177
pubmed: 32596012
Life Sci. 2016 Jan 15;145:27-33
pubmed: 26685757
Int J Mol Sci. 2019 Dec 25;21(1):
pubmed: 31881664
Sci Rep. 2014 Jun 03;4:5146
pubmed: 24888510
Int J Mol Sci. 2020 Mar 09;21(5):
pubmed: 32182774
Int J Immunopathol Pharmacol. 2013 Oct-Dec;26(4):1019-25
pubmed: 24355241
Toxicol Ind Health. 2003 Jul;19(2-6):41-9
pubmed: 15697173
Toxicol Ind Health. 1996 Mar-Apr;12(2):235-43
pubmed: 8794536
Ital J Dermatol Venerol. 2021 Apr;156(2):220-225
pubmed: 33960753
Neurotoxicol Teratol. 1989 Jul-Aug;11(4):363-71
pubmed: 2796891
Gastroenterology. 2019 Aug;157(2):365-381.e4
pubmed: 31085196
Int J Epidemiol. 2004 Oct;33(5):971-8
pubmed: 15256524
BMJ Open. 2017 Feb 22;7(2):e013879
pubmed: 28232466
Toxicol Ind Health. 1999 Oct;15(6):577-81
pubmed: 10560135
Oxid Med Cell Longev. 2013;2013:356235
pubmed: 24367721
Toxicol Sci. 2002 Jun;67(2):207-18
pubmed: 12011480
Mediators Inflamm. 2015;2015:245308
pubmed: 25878398
Arch Environ Health. 1999 May-Jun;54(3):147-9
pubmed: 10444033
Hum Exp Toxicol. 2007 Mar;26(3):231-41
pubmed: 17439926
Respir Physiol Neurobiol. 2015 Apr;209:47-51
pubmed: 25542135
Noise Health. 2016 May-Jun;18(82):143-9
pubmed: 27157687
Br J Ind Med. 1976 Aug;33(3):196-8
pubmed: 963006
Occup Med. 1987 Oct-Dec;2(4):713-20
pubmed: 3313767
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Jun;60(6):597-604
pubmed: 28447135
Neurotoxicology. 2003 Mar;24(2):179-86
pubmed: 12606290
Oxid Med Cell Longev. 2013;2013:831969
pubmed: 23936614
Environ Res. 1993 Feb;60(2):295-319
pubmed: 8472660
Toxicol Ind Health. 1992 Jul-Aug;8(4):87-94
pubmed: 1412496
Biol Psychiatry. 1998 Mar 1;43(5):376-88
pubmed: 9513754
Arch Environ Health. 2004 Jun;59(6):300-5
pubmed: 16238164
Environ Health Prev Med. 2012 Sep;17(5):357-63
pubmed: 22205546
Eur J Nucl Med Mol Imaging. 2015 Apr;42(5):733-40
pubmed: 25690545
Scand J Rheumatol. 1997;26(5):364-7
pubmed: 9385348
Toxicol Ind Health. 1999 Apr-Jun;15(3-4):370-85
pubmed: 10416289
Endocrinol Diabetes Nutr (Engl Ed). 2020 May;67(5):353-354
pubmed: 31874795
Arch Environ Health. 1995 Mar-Apr;50(2):119-29
pubmed: 7786048
Arch Otolaryngol Head Neck Surg. 1988 Dec;114(12):1422-7
pubmed: 2461210
J Psychosom Res. 2020 May;132:109964
pubmed: 32114179
Occup Med. 1987 Oct-Dec;2(4):655-61
pubmed: 3313760
Toxicol Ind Health. 1994 Jul-Oct;10(4-5):561-71
pubmed: 7778114
Environ Health Perspect. 1997 Mar;105 Suppl 2:487-94
pubmed: 9167985
J Toxicol Environ Health. 1994 Mar;41(3):275-84
pubmed: 8126750
Environ Health. 2018 Dec 14;17(1):89
pubmed: 30547814
Int J Immunopathol Pharmacol. 2013 Oct-Dec;26(4):961-4
pubmed: 24355232
Int J Hyg Environ Health. 2005;208(3):141-51
pubmed: 15971853
Neuro Endocrinol Lett. 1999;20(3-4):221-228
pubmed: 11462117
Int Arch Occup Environ Health. 2018 Nov;91(8):923-935
pubmed: 30088144
Adv Exp Med Biol. 2013;756:179-88
pubmed: 22836634
Toxicol Ind Health. 1992 Jul-Aug;8(4):95-109
pubmed: 1412497
Dermatol Ther. 2021 Mar;34(2):e14848
pubmed: 33533563
Arch Environ Health. 2003 Jul;58(7):421-32
pubmed: 15143855
Br J Anaesth. 2008 Oct;101(4):486-91
pubmed: 18782886
Toxicol Ind Health. 1999 Apr-Jun;15(3-4):386-97
pubmed: 10416290
Neuro Endocrinol Lett. 1999;20(5):289-298
pubmed: 11460087
Am J Forensic Med Pathol. 2006 Mar;27(1):42-5
pubmed: 16501347
Neurotoxicol Teratol. 1996 Jul-Aug;18(4):391-400
pubmed: 8866529
Int J Hyg Environ Health. 2005;208(4):271-8
pubmed: 16078641
Biol Psychiatry. 1992 Aug 1;32(3):218-42
pubmed: 1420641
Biol Psychiatry. 1996 Jul 15;40(2):134-43
pubmed: 8793045

Auteurs

Giovanni Damiani (G)

Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
PhD Degree Program in Pharmacological Sciences, Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.
ORCID: 0000-0002-2390-6505

Marco Alessandrini (M)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Daniela Caccamo (D)

Department of Biomedical Sciences, Dental Sciences, & Morpho-Functional Imaging, Polyclinic Hospital University, 98124 Messina, Italy.

Andrea Cormano (A)

International Society of Doctors for Environment, 82100 Benevento, Italy.
ORCID: 0000-0003-2096-706X

Gianpaolo Guzzi (G)

Italian Association for Metals and Biocompatibility Research-A.I.R.M.E.B., 20122 Milan, Italy.

Andrea Mazzatenta (A)

Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy.
ORCID: 0000-0001-5132-0029

Alessandro Micarelli (A)

Institute of Mountain Emergency Medicine, Eurac Research, 39100 Bolzano, Italy.
ITER Center for Balance and Rehabilitation Research (ICBRR), 02032 Rome, Italy.

Alberto Migliore (A)

Department of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, 00189 Rome, Italy.

Alba Piroli (A)

Department of MeSVA, University of L'Aquila, 67100 L'Aquila, Italy.
ORCID: 0000-0002-1722-6490

Margherita Bianca (M)

Ottaviano Tapparo (O)

Natrail Tagesklinik, 81925 Munchen, Germany.

Paolo Daniele Maria Pigatto (PDM)

Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Consensus › Italian Expert Consensus on Clinical and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Italian Expert Consensus on Clinical and...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Italian Expert Consensus on Clinical and...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Italian Expert Consensus on Clinical and...
questionsmedicales.fr › Troubles liés à l'environnement › Maladie environnementale › Hypersensibilité chimique multiple › Italian Expert Consensus on Clinical and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Italian Expert Consensus on Clinical and...