CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ.
angiogenesis
medication-related osteonecrosis of the jaw
surgical treatment
treatment outcome
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
29 10 2021
29 10 2021
Historique:
received:
06
09
2021
revised:
16
10
2021
accepted:
23
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, "healed" and "not healed". Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.
Identifiants
pubmed: 34769880
pii: ijerph182111362
doi: 10.3390/ijerph182111362
pmc: PMC8582901
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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