Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Biomarkers
Cell Line, Tumor
Cell Proliferation
/ drug effects
Chemistry Techniques, Synthetic
Drug Design
Flow Cytometry
Humans
Membrane Potential, Mitochondrial
/ drug effects
Metabolic Networks and Pathways
/ drug effects
Mitochondria
/ drug effects
Molecular Structure
Reactive Oxygen Species
/ metabolism
Semicarbazones
/ chemical synthesis
Triterpenes
/ chemistry
antitumor
apoptosis
betulin derivatives
semicarbazone
thiosemicarbazone
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Oct 2021
21 Oct 2021
Historique:
received:
22
09
2021
revised:
11
10
2021
accepted:
19
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Two new series of betulin derivatives with semicarbazone (
Identifiants
pubmed: 34770765
pii: molecules26216356
doi: 10.3390/molecules26216356
pmc: PMC8587101
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers
0
Reactive Oxygen Species
0
Semicarbazones
0
Triterpenes
0
betulin
6W70HN7X7O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Central Government Support Fund for the Reform and Development of Local Universities-Talent Training Support Program Project
ID : ZYZX2019
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