Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials.
absorbance
antiviral activity
cotton fabric
emission
hemorphins
rhodamine-peptides
virucidal effect
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
31 Oct 2021
31 Oct 2021
Historique:
received:
15
10
2021
revised:
27
10
2021
accepted:
29
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3.
Identifiants
pubmed: 34771015
pii: molecules26216608
doi: 10.3390/molecules26216608
pmc: PMC8587962
pii:
doi:
Substances chimiques
Antiviral Agents
0
Peptides
0
Rhodamines
0
rhodamine B
K7G5SCF8IL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bulgarian National Scientific Fund
ID : project КП-06-ДК1/11
Organisme : Ministry of Education and Science
ID : КП-06-ДК1/11
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