The Role of Circular RNAs in DNA Damage Response and Repair.
DNA damage response and repair (DDRR)
circRNA
double-strand breaks (DSB)
tumorigenesis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Oct 2021
26 Oct 2021
Historique:
received:
08
09
2021
revised:
15
10
2021
accepted:
15
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
14
11
2021
Statut:
epublish
Résumé
Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.
Identifiants
pubmed: 34771517
pii: cancers13215352
doi: 10.3390/cancers13215352
pmc: PMC8582540
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Hellenic Foundation for Research and Innovation
ID : 775, 3782
Organisme : National Public Investment Program of the Ministry of Development and Investment/General Secretariat for Research and Technology
ID : 2020ΣΕ01300001
Organisme : Greece and the European Union (European Social Fund- ESF), State Scholarships Foundation (ΙΚΥ)
ID : MIS-5033021
Organisme : Welfare Foundation for Social & Cultural Sciences (KIKPE)
ID : donation
Organisme : H. Pappas
ID : donation
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