Immune Checkpoint Inhibitors for Genitourinary Cancers: Treatment Indications, Investigational Approaches and Biomarkers.
bladder cancer
genitourinary cancer
immune checkpoint inhibitors
immunotherapy
kidney
prostate
testicular
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Oct 2021
28 Oct 2021
Historique:
received:
26
08
2021
revised:
14
10
2021
accepted:
15
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
14
11
2021
Statut:
epublish
Résumé
Cancers of the genitourinary (GU) tract are common malignancies in both men and women and are a major source of morbidity and mortality. Immune checkpoint inhibitors (ICI) targeting CTLA-4, PD-1 or PD-L1 have provided clinical benefit, particularly in renal cell and urothelial carcinoma, and have been incorporated into standard of care treatment in both localized and metastatic settings. However, a large fraction of patients do not derive benefit. Identification of patient and tumor-derived factors which associate with response have led to insights into mechanisms of response and resistance to ICI. Herein, we review current approvals and clinical development of ICI in GU malignancies and discuss exploratory biomarkers which aid in personalized treatment selection.
Identifiants
pubmed: 34771578
pii: cancers13215415
doi: 10.3390/cancers13215415
pmc: PMC8582522
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Science. 2013 Nov 22;342(6161):967-70
pubmed: 24264989
Eur Urol Oncol. 2020 Dec;3(6):728-738
pubmed: 33177001
Oncologist. 2019 Dec;24(12):1526-1533
pubmed: 31292271
Cancer Cell. 2017 May 8;31(5):711-723.e4
pubmed: 28486109
Cell. 2015 May 21;161(5):1215-1228
pubmed: 26000489
Vaccines (Basel). 2021 Feb 09;9(2):
pubmed: 33572196
J Clin Invest. 2017 Jan 3;127(1):1-4
pubmed: 28045402
Cancer. 2001 Jun 15;91(12):2417-22
pubmed: 11413533
J Clin Oncol. 2018 Dec 1;36(34):3353-3360
pubmed: 30343614
JAMA Oncol. 2019 Apr 01;5(4):471-478
pubmed: 30589920
J Immunother Cancer. 2017 Oct 17;5(1):82
pubmed: 29041991
Nature. 2018 Feb 22;554(7693):544-548
pubmed: 29443960
Mod Pathol. 2021 Dec;34(12):2229-2241
pubmed: 34215851
Urology. 2015 Mar;85(3):703.e1-6
pubmed: 25733301
Curr Oncol Rep. 2020 Jun 24;22(7):74
pubmed: 32577835
Cancer. 2020 Feb 1;126(3):575-582
pubmed: 31648379
Science. 2021 Feb 5;371(6529):602-609
pubmed: 33303685
N Engl J Med. 2015 Nov 5;373(19):1803-13
pubmed: 26406148
Cell. 2020 Dec 23;183(7):1848-1866.e26
pubmed: 33301708
Science. 2018 Feb 16;359(6377):801-806
pubmed: 29301960
Eur Urol. 2020 Dec;78(6):822-830
pubmed: 32811715
Cancer Discov. 2017 Dec;7(12):1394-1403
pubmed: 28899864
J Clin Invest. 2017 Aug 1;127(8):2930-2940
pubmed: 28650338
N Engl J Med. 2021 Apr 8;384(14):1289-1300
pubmed: 33616314
J Immunother Cancer. 2019 Oct 24;7(1):275
pubmed: 31651359
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Lancet. 2016 May 7;387(10031):1909-20
pubmed: 26952546
Lancet. 2018 Feb 24;391(10122):748-757
pubmed: 29268948
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
J Clin Oncol. 2020 Feb 10;38(5):395-405
pubmed: 31774688
J Clin Oncol. 2022 Jul 20;40(21):2333-2341
pubmed: 35298296
Urol Oncol. 2021 Jul;39(7):437.e1-437.e9
pubmed: 33495117
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7759-E7768
pubmed: 27837020
J Clin Oncol. 2008 Dec 20;26(36):5950-6
pubmed: 19018089
Br J Cancer. 2020 Feb;122(4):555-563
pubmed: 31857723
Lancet Oncol. 2017 Mar;18(3):312-322
pubmed: 28131785
J Immunother Cancer. 2015 Jun 16;3:23
pubmed: 26085931
Nature. 2020 Jan;577(7791):549-555
pubmed: 31942075
J Immunol. 2008 Jul 1;181(1):346-53
pubmed: 18566400
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Cell. 2018 Jun 14;173(7):1770-1782.e14
pubmed: 29906450
J Clin Oncol. 2016 Dec 10;34(35):4270-4276
pubmed: 27903155
Science. 2020 Jan 31;367(6477):
pubmed: 32001626
J Clin Oncol. 2003 Jun 15;21(12):2342-8
pubmed: 12805336
Cancer Res. 2009 Apr 1;69(7):3077-85
pubmed: 19293190
Physiol Rev. 2011 Jul;91(3):1071-121
pubmed: 21742796
Ann Oncol. 2021 May;32(5):661-672
pubmed: 33736924
JCO Precis Oncol. 2017;2017:
pubmed: 29850653
Clin Cancer Res. 2014 Oct 1;20(19):5064-74
pubmed: 24714771
Nat Med. 2019 Nov;25(11):1706-1714
pubmed: 31686036
Ann Oncol. 2015 Apr;26(4):812-817
pubmed: 25600565
Clin Cancer Res. 2015 Jul 1;21(13):3031-40
pubmed: 25688160
Cancer Manag Res. 2019 May 08;11:4171-4184
pubmed: 31190987
Lancet Oncol. 2018 Jan;19(1):51-64
pubmed: 29217288
J Clin Oncol. 1995 Mar;13(3):688-96
pubmed: 7884429
Cancer J. 2010 Jul-Aug;16(4):399-403
pubmed: 20693853
Lancet. 2019 Jun 15;393(10189):2404-2415
pubmed: 31079938
N Engl J Med. 2012 Jun 28;366(26):2443-54
pubmed: 22658127
Lancet Oncol. 2019 Feb;20(2):297-310
pubmed: 30658932
Clin Cancer Res. 2019 Dec 1;25(23):6909-6915
pubmed: 31285372
Clin Cancer Res. 2021 Jan 15;27(2):566-574
pubmed: 32988971
Cancer Cell. 2020 Oct 12;38(4):489-499.e3
pubmed: 32916128
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11701-E11710
pubmed: 30463956
J Clin Oncol. 2009 Dec 1;27(34):5794-9
pubmed: 19826129
Nature. 2016 Jul 06;535(7610):75-84
pubmed: 27383982
Nat Genet. 2015 Apr;47(4):320-9
pubmed: 25706628
Cancer. 2020 Sep 15;126(18):4156-4167
pubmed: 32673417
N Engl J Med. 2019 Mar 21;380(12):1116-1127
pubmed: 30779529
Ann Oncol. 2018 Aug 1;29(8):1807-1813
pubmed: 29992241
World J Urol. 1995;13(3):153-8
pubmed: 7550386
Lancet Oncol. 2020 Feb;21(2):283-293
pubmed: 31870811
Clin Cancer Res. 2016 Nov 15;22(22):5461-5471
pubmed: 27169994
J Clin Oncol. 2020 Jan 1;38(1):63-70
pubmed: 31721643
Nat Cancer. 2020 Feb;1(2):176-183
pubmed: 34505064
J Clin Oncol. 2019 Dec 10;37(35):3350-3358
pubmed: 31498030
Nat Rev Clin Oncol. 2017 Dec;14(12):717-734
pubmed: 28741618
Lancet Oncol. 2017 Nov;18(11):1483-1492
pubmed: 28967485
Cancer Immunol Res. 2018 Sep;6(9):990-1000
pubmed: 30181337
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Eur Urol Oncol. 2019 Jul;2(4):355-364
pubmed: 31277773
N Engl J Med. 2018 Apr 05;378(14):1277-1290
pubmed: 29562145
Nature. 2014 Nov 27;515(7528):563-7
pubmed: 25428504
Lancet Oncol. 2021 Jul;22(7):919-930
pubmed: 34051177
N Engl J Med. 2015 May 21;372(21):2018-28
pubmed: 25891174
Br J Urol. 1997 Nov;80(5):762-5
pubmed: 9393299
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
BMC Cancer. 2008 Apr 30;8:122
pubmed: 18447912
Nat Immunol. 2012 Jul 19;13(8):707-12
pubmed: 22814340
Oncotarget. 2018 Jan 20;9(9):8706-8715
pubmed: 29492229
Nat Med. 2018 Dec;24(12):1804-1808
pubmed: 30420754
J Clin Oncol. 2020 Jan 1;38(1):1-10
pubmed: 31682550
Lancet Oncol. 2021 Jul;22(7):931-945
pubmed: 34051178
Clin Cancer Res. 2015 Mar 1;21(5):1071-7
pubmed: 25538263
N Engl J Med. 2020 Sep 24;383(13):1218-1230
pubmed: 32945632
Cancers (Basel). 2020 Nov 16;12(11):
pubmed: 33207823
J Clin Oncol. 2020 Nov 1;38(31):3672-3684
pubmed: 32915679
Lancet Oncol. 2021 Jul;22(7):946-958
pubmed: 34143969
N Engl J Med. 2007 Jan 11;356(2):115-24
pubmed: 17215529
JCO Precis Oncol. 2020;4:370-381
pubmed: 32462107
Lancet Oncol. 2021 Apr;22(4):525-537
pubmed: 33721560
Clin Cancer Res. 2013 Jul 1;19(13):3681-92
pubmed: 23685835
Nat Metab. 2020 Jan;2(1):50-61
pubmed: 32694683
Eur J Surg Oncol. 2014 Dec;40(12):1738-45
pubmed: 25454826
Sci Transl Med. 2020 Apr 1;12(537):
pubmed: 32238575
Science. 2018 Jan 5;359(6371):104-108
pubmed: 29302014
Ann Oncol. 2019 Jun 1;30(6):970-976
pubmed: 31050707
Eur Urol. 2020 Apr;77(4):439-446
pubmed: 31708296
Lancet Oncol. 2017 Aug;18(8):1009-1021
pubmed: 28694034
Front Oncol. 2019 May 28;9:439
pubmed: 31192136
Eur Urol. 2020 Oct;78(4):498-502
pubmed: 32828600
Science. 2015 Nov 27;350(6264):1084-9
pubmed: 26541606
Trends Cancer. 2016 Mar;2(3):121-133
pubmed: 28741532
J Clin Oncol. 2017 Jan;35(1):40-47
pubmed: 28034081
Nature. 2020 Jan;577(7791):561-565
pubmed: 31942071
N Engl J Med. 2019 Mar 21;380(12):1103-1115
pubmed: 30779531
Nat Rev Drug Discov. 2019 Mar;18(3):197-218
pubmed: 30610226
Eur J Cancer. 2021 May;148:181-189
pubmed: 33743486
Cancer Immunol Immunother. 2012 Jul;61(7):1019-31
pubmed: 22146893
JCI Insight. 2021 Jan 25;6(2):
pubmed: 33320838
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
J Transl Med. 2019 Nov 25;17(1):386
pubmed: 31767020
Mol Metab. 2020 Mar;33:102-121
pubmed: 31399389
J Immunother Cancer. 2018 Jan 22;6(1):5
pubmed: 29353553
Lancet Oncol. 2014 Jun;15(7):700-12
pubmed: 24831977
Nat Med. 2020 Jun;26(6):909-918
pubmed: 32472114
Nat Med. 2019 Jan;25(1):141-151
pubmed: 30420753
Lancet. 2017 Jan 7;389(10064):67-76
pubmed: 27939400
Cell. 2016 Nov 3;167(4):1099-1110.e14
pubmed: 27814507
Ann Oncol. 2018 Jan 1;29(1):209-214
pubmed: 29045540
Nature. 2017 May 4;545(7652):60-65
pubmed: 28397821
Oncologist. 2019 Apr;24(4):e142-e145
pubmed: 30659078
JAMA Oncol. 2017 Sep 14;3(9):e172411
pubmed: 28817753
Nat Med. 2020 Nov;26(11):1733-1741
pubmed: 32895571
Lancet Oncol. 2020 Dec;21(12):1563-1573
pubmed: 33284113
Science. 2015 Nov 27;350(6264):1079-84
pubmed: 26541610
Lancet. 2008 Aug 9;372(9637):449-56
pubmed: 18653228
Lancet. 2020 May 16;395(10236):1547-1557
pubmed: 32416780
N Engl J Med. 2017 Mar 16;376(11):1015-1026
pubmed: 28212060
Front Oncol. 2020 Sep 24;10:573977
pubmed: 33072608
Invest New Drugs. 2019 Aug;37(4):748-754
pubmed: 31152292
J Clin Oncol. 2018 Jun 10;36(17):1685-1694
pubmed: 29489427
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
J Immunol. 1998 Feb 1;160(3):1224-32
pubmed: 9570538
J Immunother Cancer. 2019 May 16;7(1):127
pubmed: 31097024
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2729-34
pubmed: 19202079
J Immunother Cancer. 2020 Dec;8(2):
pubmed: 33427691
Nat Rev Cancer. 2013 Nov;13(11):800-12
pubmed: 24132111
Lancet Oncol. 2018 Mar;19(3):310-322
pubmed: 29449192
N Engl J Med. 2020 May 28;382(22):2091-2102
pubmed: 32343890
Nat Commun. 2018 Nov 8;9(1):4692
pubmed: 30410077
Clin Cancer Res. 2013 Jul 15;19(14):3905-13
pubmed: 23743570
J Clin Oncol. 2017 Dec 1;35(34):3851-3858
pubmed: 28678668
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
Nat Med. 2018 Jun;24(6):749-757
pubmed: 29867230
J Clin Oncol. 2020 Sep 20;38(27):3129-3137
pubmed: 32716740
Nat Med. 1996 Oct;2(10):1096-103
pubmed: 8837607
Eur Urol. 2019 Jan;75(1):201-203
pubmed: 30243800
J Clin Oncol. 2002 Jan 1;20(1):289-96
pubmed: 11773181
Cancer Immunol Res. 2016 Nov;4(11):903-909
pubmed: 27638840
Cancer Res. 2019 Jan 15;79(2):311-319
pubmed: 30482774
J Clin Oncol. 2020 Nov 10;38(32):3763-3772
pubmed: 32795228
JAMA Oncol. 2019 Nov 1;5(11):1631-1633
pubmed: 31486842
Nat Immunol. 2013 Oct;14(10):1014-22
pubmed: 24048123
Nat Rev Cancer. 2006 Nov;6(11):857-66
pubmed: 17060945
J Exp Med. 2015 Feb 9;212(2):139-48
pubmed: 25601652
Science. 2017 Jul 28;357(6349):409-413
pubmed: 28596308
J Clin Oncol. 2016 Mar 10;34(8):833-42
pubmed: 26755520
Nat Genet. 2019 Feb;51(2):202-206
pubmed: 30643254
Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6681-8
pubmed: 17982122
Nat Commun. 2021 Mar 3;12(1):1426
pubmed: 33658518
Oncotarget. 2015 Oct 6;6(30):28999-9015
pubmed: 26338962