Fracture prevalence in thalassemia: a systematic review and meta-analysis.
Fracture
Meta-analysis
Systematic review
Thalassemia
Journal
Archives of osteoporosis
ISSN: 1862-3514
Titre abrégé: Arch Osteoporos
Pays: England
ID NLM: 101318988
Informations de publication
Date de publication:
13 11 2021
13 11 2021
Historique:
received:
27
08
2021
accepted:
11
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Multiple observational studies have reported high prevalence of fracture in patients with thalassemia. However, most of these studies have included limited number of patients, and only few of them have reported prevalence of fracture among patients with different types and severity of thalassemia. This systematic review and meta-analysis was conducted to summarize all available data of fracture prevalence among patients with thalassemia. A systematic review was conducted using EMBASE and MEDLINE databases from inception to June 2021 to determine studies that reported prevalence of fracture in thalassemia patients. The pooled prevalence with 95% confidence interval (95%CI) of fracture across studies was determined using a random-effect, generic inverse variance method. After two rounds of systematic review, a total of 25 studies with 4934 patients were included in the meta-analysis. The pooled prevalence of fracture among patients with thalassemia was 16% (95%CI, 15-17%, I Fracture is common in patients with thalassemia, and may be more prevalent in beta thalassemia and transfusion-dependent thalassemia than in alpha thalassemia and non-transfusion-dependent thalassemia.
Sections du résumé
BACKGROUND
Multiple observational studies have reported high prevalence of fracture in patients with thalassemia. However, most of these studies have included limited number of patients, and only few of them have reported prevalence of fracture among patients with different types and severity of thalassemia.
OBJECTIVE
This systematic review and meta-analysis was conducted to summarize all available data of fracture prevalence among patients with thalassemia.
METHODS
A systematic review was conducted using EMBASE and MEDLINE databases from inception to June 2021 to determine studies that reported prevalence of fracture in thalassemia patients. The pooled prevalence with 95% confidence interval (95%CI) of fracture across studies was determined using a random-effect, generic inverse variance method.
RESULTS
After two rounds of systematic review, a total of 25 studies with 4934 patients were included in the meta-analysis. The pooled prevalence of fracture among patients with thalassemia was 16% (95%CI, 15-17%, I
CONCLUSION
Fracture is common in patients with thalassemia, and may be more prevalent in beta thalassemia and transfusion-dependent thalassemia than in alpha thalassemia and non-transfusion-dependent thalassemia.
Identifiants
pubmed: 34773506
doi: 10.1007/s11657-021-01026-0
pii: 10.1007/s11657-021-01026-0
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
171Informations de copyright
© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation.
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