Myeloproliferative Neoplasms with Monocytosis.

Humans Janus Kinase 2 / genetics Leukocytosis Mutation Myeloproliferative Disorders / diagnosis Polycythemia Vera / diagnosis Thrombocythemia, Essential
Chronic myelomonocytic leukemia Monocytosis Myeloproliferative neoplasm Prognosis

Journal

Current hematologic malignancy reports
ISSN: 1558-822X
Titre abrégé: Curr Hematol Malig Rep
Pays: United States
ID NLM: 101262565

Informations de publication

Date de publication:
02 2022
Historique:
accepted: 12 10 2021
pubmed: 14 11 2021
medline: 10 5 2022
entrez: 13 11 2021
Statut: ppublish

Résumé

Myeloproliferative neoplasms (MPN) are a heterogeneous group of hematopoietic stem cell neoplasms comprising of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) that share driver mutations (JAK2/CALR/MPL) resulting in constitutive activation of JAK/STAT and other signaling pathways. Patients with MPN have shortened survival and an inherent risk for leukemic evolution. Prognostically relevant clinical and genetic parameters have been incorporated into mutation-enhanced scoring systems (MIPSS70-plus version 2.0, MIPSS-ET/PV). In the current review, we describe clinical and pathological features along with prognostic significance of MPN with monocytosis. Monocytosis, defined by an absolute monocyte count (AMC) ≥ 1 × 10

Identifiants

DOI: 10.1007/s11899-021-00660-2 PMID: 34773576
pubmed: 34773576
doi: 10.1007/s11899-021-00660-2
pii: 10.1007/s11899-021-00660-2
doi:

Substances chimiques

Janus Kinase 2 EC 2.7.10.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-51

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Auteurs

Erika Morsia (E)

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0003-4453-6985

Naseema Gangat (N)

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. gangat.naseema@mayo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinase Janus-2 › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hyperleucocytose › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myéloprolifératifs › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › Tumeurs de la moelle osseuse › Polyglobulie primitive essentielle › Myeloproliferative Neoplasms with Monocytosis.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Troubles hémorragiques › Thrombocytémie essentielle › Myeloproliferative Neoplasms with Monocytosis.