Imaging of astrocytes in posttraumatic stress disorder: A PET study with the monoamine oxidase B radioligand [

Astrocytes / metabolism Brain / diagnostic imaging Depressive Disorder, Major / metabolism Humans Isoxazoles Monoamine Oxidase / metabolism Oxazolidinones Positron-Emission Tomography / methods Stress Disorders, Post-Traumatic / diagnostic imaging
Astrocytes MAO-B PTSD Positron emission tomography Posttraumatic stress disorder

Journal

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390

Informations de publication

Date de publication:
01 2022
Historique:
received: 24 05 2021
revised: 11 10 2021
accepted: 12 10 2021
pubmed: 14 11 2021
medline: 12 4 2022
entrez: 13 11 2021
Statut: ppublish

Résumé

Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that results from exposure to traumatic event(s). Decreased astrocyte-related proteins (e.g., glial fibrillary acidic protein, GFAP) and atrophic astrocytes in corticolimbic brain areas implicated in PTSD have been reported in experimental models suggesting that astrocyte pathology may be a feature of this disorder. We used positron emission tomography (PET) of the monoamine oxidase (MAO)-B probe [

Identifiants

DOI: 10.1016/j.euroneuro.2021.10.006 PMID: 34773851
pubmed: 34773851
pii: S0924-977X(21)00776-8
doi: 10.1016/j.euroneuro.2021.10.006
pii:
doi:

Substances chimiques

Isoxazoles 0
Oxazolidinones 0
SL25.1188 0
Monoamine Oxidase EC 1.4.3.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-61

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare no conflict of interest.

Auteurs

Talwinder Gill (T)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Sarah E Watling (SE)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

J Don Richardson (JD)

The MacDonald Franklin OSI Research Centre, Lawson Health Research Institute, London, ON, Canada; Department of Psychiatry, Western University, London, Ontario, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada; St Joseph's, London OSI, Parkwood Institute, St. Joseph's Health Care, London, Ontario, Canada.

Tina McCluskey (T)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Junchao Tong (J)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Jeffrey H Meyer (JH)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Jerry Warsh (J)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Rakesh Jetly (R)

Directorate of Mental Health, Canadian Forces Health Services, Ottawa, ON, Canada; Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada.

Michael G Hutchison (MG)

Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada; David L. MacIntosh Sport Medicine Clinic, Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.

Shawn G Rhind (SG)

Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada; Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada.

Sylvain Houle (S)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Neil Vasdev (N)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Azrieli Centre for Neuro-Radiochemistry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Stephen J Kish (SJ)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Isabelle Boileau (I)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: isabelle.boileau@camh.ca.

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Classifications MeSH

questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Isoxazoles › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxazolidinones › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Imaging of astrocytes in posttraumatic stress...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Imaging of astrocytes in posttraumatic stress...