Prognostic implication of desmoplastic stroma in synovial sarcoma: A histological review.
Cancer-associated fibroblast
Desmoplastic reaction
Hyalinized collagenous stroma
Synovial sarcoma
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
30
07
2021
revised:
20
10
2021
accepted:
21
10
2021
pubmed:
14
11
2021
medline:
4
3
2022
entrez:
13
11
2021
Statut:
ppublish
Résumé
Synovial sarcoma (SS) is a malignant soft tissue neoplasm harboring SS18-SSX fusion gene and is histologically characterized by spindle cells and epithelial components. Some investigations have demonstrated that desmoplastic reaction (DR) is an independent prognostic factor of cancers. However, it remains unknown whether DR is of predictive value for the prognosis of synovial sarcoma patients. Here, we reviewed the clinical and histological findings of 88 patients with SS. We defined DR as hyalinized collagenous structures and classified the degree of DR as follows: none, mild, moderate, and severe. Overall, 23 SS cases (24%) showed moderate or severe DR histologically. Statistically, the cases with moderate or severe degree of DR showed poorer prognosis than those with no or mild DR (local recurrence: P = 0.0059, distant metastasis: P = 0.0002, tumor death: P = 0.0382). The findings of the study suggest that the DR of synovial sarcoma could be an important prognostic factor.
Identifiants
pubmed: 34773915
pii: S0344-0338(21)00329-0
doi: 10.1016/j.prp.2021.153668
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153668Informations de copyright
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