Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone.

Humans Hypercalcemia / etiology Parathyroid Hormone Parathyroid Neoplasms / complications
CDC73 HPT-JT Hypercalcemia PI3K/AKT/mTOR PTH Parafibromin Primary hyperparathyroidism

Journal

Endocrinology and metabolism clinics of North America
ISSN: 1558-4410
Titre abrégé: Endocrinol Metab Clin North Am
Pays: United States
ID NLM: 8800104

Informations de publication

Date de publication:
12 2021
Historique:
entrez: 14 11 2021
pubmed: 15 11 2021
medline: 1 4 2022
Statut: ppublish

Résumé

The most common causes of hypercalcemia are primary hyperparathyroidism (PHPT) and malignancy. Parathyroid carcinoma (PC), causing a severe PHPT, is the rarest parathyroid tumor. A diagnosis of PC is challenging because the clinical profile overlaps with that of benign counterpart. Surgery is the mainstay treatment. CDC73 mutations have been detected in up to 80% of sporadic PCs. Ectopic production of parathyroid hormone (PTH) by malignant nonparathyroid tumors is a rare condition accounting for less than 1% of hypercalcemia of malignancy. PTH secretion can be considered an aberration in the tissue specificity of gene expression and may involve heterogeneous molecular mechanisms.

Identifiants

DOI: 10.1016/j.ecl.2021.07.001 PMID: 34774241
pubmed: 34774241
pii: S0889-8529(21)00054-2
doi: 10.1016/j.ecl.2021.07.001
pii:
doi:

Substances chimiques

Parathyroid Hormone 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

683-709

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Filomena Cetani (F)

University Hospital of Pisa, Endocrine Unit 2, Via Paradisa, 2, Pisa 56124, Italy. Electronic address: cetani@endoc.med.unipi.it.

Elena Pardi (E)

Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa, 2, Pisa 56124, Italy.

Claudio Marcocci (C)

University Hospital of Pisa, Endocrine Unit 2, Via Paradisa, 2, Pisa 56124, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa, 2, Pisa 56124, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Parathyroid Carcinoma and Ectopic Secretion of...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'équilibre hydroélectrolytique › Hypercalcémie › Parathyroid Carcinoma and Ectopic Secretion of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Parathyroid Carcinoma and Ectopic Secretion of...
questionsmedicales.fr › Maladies endocriniennes › Maladies de la parathyroïde › Tumeurs de la parathyroïde › Parathyroid Carcinoma and Ectopic Secretion of...