The role of cholesterol recognition (CARC/CRAC) mirror codes in the allosterism of the human organic cation transporter 2 (OCT2, SLC22A2).

Allosteric Regulation / physiology Amino Acid Sequence Cholesterol / genetics HEK293 Cells Humans Organic Cation Transporter 2 / chemistry Protein Structure, Secondary
Allosterism CARC CRAC Cholesterol Organic cation transporter Thermal shift assay

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
12 2021
Historique:
received: 06 10 2021
revised: 08 11 2021
accepted: 09 11 2021
pubmed: 15 11 2021
medline: 4 1 2022
entrez: 14 11 2021
Statut: ppublish

Résumé

The human organic cation transporter 2 (OCT2) is a multispecific transporter with cholesterol-dependent allosteric features. The present work elucidates the role of evolutionarily conserved cholesterol recognition/interaction amino acid consensus sequences (CRAC and CARC) in the allosteric binding to 1-methyl-4-phenylpyridinium (MPP

Identifiants

DOI: 10.1016/j.bcp.2021.114840 PMID: 34774844
pubmed: 34774844
pii: S0006-2952(21)00456-1
doi: 10.1016/j.bcp.2021.114840
pii:
doi:

Substances chimiques

Organic Cation Transporter 2 0
SLC22A2 protein, human 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114840

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Morena L Sutter (ML)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Lara Console (L)

Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy.

Anne-Fleur Fahner (AF)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Sophia L Samodelov (SL)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Zhibo Gai (Z)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China.

Giuliano Ciarimboli (G)

Experimental Nephrology, Medicine Clinic D, University Hospital Münster, Münster, Germany.

Cesare Indiveri (C)

Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy.

Gerd A Kullak-Ublick (GA)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Michele Visentin (M)

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address: Michele.visentin@usz.ch.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › The role of cholesterol recognition...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › The role of cholesterol recognition...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › The role of cholesterol recognition...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › The role of cholesterol recognition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The role of cholesterol recognition...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de cations organiques › Transporteur-2 de cations organiques › The role of cholesterol recognition...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › The role of cholesterol recognition...