NF-κB1 Contributes to Imiquimod-Induced Psoriasis-Like Skin Inflammation by Inducing Vγ4

Animals Dermatitis / pathology Disease Models, Animal Imiquimod Inflammation / pathology Interleukin-17 / metabolism Mice Mice, Inbred BALB C Psoriasis / chemically induced Skin / pathology

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
06 2022
Historique:
received: 14 07 2021
revised: 04 10 2021
accepted: 04 11 2021
pubmed: 15 11 2021
medline: 25 5 2022
entrez: 14 11 2021
Statut: ppublish

Résumé

Recent studies have identified NF-κB1 as a new disease susceptibility gene for psoriasis. Although accumulating evidence has shown the importance of NF-κB signaling in various cell types in the pathogenesis of psoriasis, it remains unclear how NF-κB1 contributes to the pathogenesis of psoriasis. In this study, we examined psoriasis-like skin diseases induced by topical administration of imiquimod in Nf-κb1‒deficient (Nf-κb1

Identifiants

DOI: 10.1016/j.jid.2021.11.004 PMID: 34774872
pubmed: 34774872
pii: S0022-202X(21)02483-0
doi: 10.1016/j.jid.2021.11.004
pii:
doi:

Substances chimiques

Interleukin-17 0
Imiquimod P1QW714R7M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1639-1649.e5

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Kazumasa Suzuki (K)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Kotaro Suzuki (K)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: suzuki_k@faculty.chiba-u.jp.

Yoko Yabe (Y)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Kazuma Iida (K)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Junichi Ishikawa (J)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Sohei Makita (S)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Takahiro Kageyama (T)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Taro Iwamoto (T)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Shigeru Tanaka (S)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Masaya Yokota (M)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Arifumi Iwata (A)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Akira Suto (A)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Hiroshi Nakajima (H)

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatite › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Imiquimod › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › NF-κB1 Contributes to Imiquimod-Induced...
questionsmedicales.fr › Système tégumentaire › Peau › NF-κB1 Contributes to Imiquimod-Induced...