Proton density water fraction as a reproducible MR-based measurement of breast density.
breast MRI
breast density
chemical shift encoded fat-water MRI
proton density water fraction
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
06
10
2021
received:
20
06
2021
accepted:
19
10
2021
pubmed:
15
11
2021
medline:
17
3
2022
entrez:
14
11
2021
Statut:
ppublish
Résumé
To introduce proton density water fraction (PDWF) as a confounder-corrected (CC) MR-based biomarker of mammographic breast density, a known risk factor for breast cancer. Chemical shift encoded (CSE) MR images were acquired using a low flip angle to provide proton density contrast from multiple echo times. Fat and water images, corrected for known biases, were produced by a six-echo CC CSE-MRI algorithm. Fibroglandular tissue (FGT) volume was calculated from whole-breast segmented PDWF maps at 1.5T and 3T. The method was evaluated in (1) a physical fat-water phantom and (2) normal volunteers. Results from two- and three-echo CSE-MRI methods were included for comparison. Six-echo CC-CSE-MRI produced unbiased estimates of the total water volume in the phantom (mean bias 3.3%) and was reproducible across protocol changes (repeatability coefficient [RC] = 14.8 cm The use of six-echo CC-CSE-MRI to create unbiased PDWF maps that reproducibly quantify FGT in the breast is demonstrated. Further studies are needed to correlate this quantitative MR biomarker for breast density with mammography and overall risk for breast cancer.
Identifiants
pubmed: 34775638
doi: 10.1002/mrm.29076
pmc: PMC8886798
mid: NIHMS1750431
doi:
Substances chimiques
Protons
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1742-1757Subventions
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK083380
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100651
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK102595
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014520
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK088925
Pays : United States
Informations de copyright
© 2021 International Society for Magnetic Resonance in Medicine.
Références
Acad Radiol. 2013 May;20(5):560-8
pubmed: 23465381
Radiology. 2017 May;283(2):438-449
pubmed: 28278002
Magn Reson Med. 2014 Aug;72(2):464-70
pubmed: 24123362
Magn Reson Med. 2011 Jul;66(1):199-206
pubmed: 21695724
Magn Reson Med. 2004 Aug;52(2):415-9
pubmed: 15282827
Med Phys. 2008 Dec;35(12):5253-62
pubmed: 19175084
NMR Biomed. 2016 Jun;29(6):702-8
pubmed: 27061174
J Magn Reson Imaging. 2013 Mar;37(3):707-16
pubmed: 23055365
Radiology. 2016 Apr;279(1):65-74
pubmed: 26491909
Diagnostics (Basel). 2017 May 31;7(2):
pubmed: 28561776
Magn Reson Imaging. 2010 Jan;28(1):8-15
pubmed: 19631485
Magn Reson Med. 2005 Oct;54(4):1032-9
pubmed: 16142718
Transl Oncol. 2015 Dec;8(6):435-45
pubmed: 26692524
Phys Med Biol. 2012 Nov 7;57(21):6903-27
pubmed: 23044556
Magn Reson Med. 2016 Feb;75(2):845-51
pubmed: 25845713
Magn Reson Imaging. 2011 Oct;29(8):1041-6
pubmed: 21868182
Magn Reson Med. 2012 Mar;67(3):638-44
pubmed: 21713978
Med Phys. 2011 Nov;38(11):5961-8
pubmed: 22047360
Radiology. 2015 May;275(2):356-65
pubmed: 25559234
Magn Reson Med. 2007 Aug;58(2):354-64
pubmed: 17654578
Med Phys. 2004 Apr;31(4):933-42
pubmed: 15125012
Magn Reson Med. 2010 Jan;63(1):79-90
pubmed: 19859956
J Magn Reson Imaging. 2007 Oct;26(4):1153-61
pubmed: 17896369
J Magn Reson Imaging. 2015 Nov;42(5):1241-8
pubmed: 25828696
J Natl Cancer Inst. 2010 Aug 18;102(16):1224-37
pubmed: 20616353
Breast Cancer Res. 2009;11(6):R80
pubmed: 19903338
PLoS One. 2013 Dec 04;8(12):e81653
pubmed: 24324712
AJR Am J Roentgenol. 2016 May;206(5):1056-62
pubmed: 26934689
Magn Reson Med. 2008 Nov;60(5):1122-34
pubmed: 18956464
J Clin Imaging Sci. 2019 Oct 11;9:43
pubmed: 31662951
PLoS One. 2016 Mar 24;11(3):e0152152
pubmed: 27011312
J Magn Reson Imaging. 2006 Jan;23(1):87-91
pubmed: 16315211
Radiology. 2008 Feb;246(2):348-53
pubmed: 18227535
Magn Reson Med. 1997 May;37(5):723-9
pubmed: 9126946
Radiology. 2015 Jul;276(1):129-36
pubmed: 25658037
Breast J. 2013 Jan-Feb;19(1):79-86
pubmed: 23230974
AJR Am J Roentgenol. 2015 Feb;204(2):W141-9
pubmed: 25615774
J Natl Cancer Inst. 2004 Oct 6;96(19):1432-40
pubmed: 15467032
J Magn Reson Imaging. 2018 Apr;47(4):995-1002
pubmed: 28851124
Med Phys. 2012 Oct;39(10):5835-48
pubmed: 23039622
Radiology. 2016 Jun;279(3):710-9
pubmed: 26694052
Med Phys. 2015 May;42(5):2268-75
pubmed: 25979021
Med Phys. 2013 Dec;40(12):122302
pubmed: 24320533
Radiology. 2015 May;275(2):366-76
pubmed: 25734553
J Magn Reson Imaging. 2018 Oct;48(4):971-981
pubmed: 29630755
Breast Cancer Res. 2018 Feb 05;20(1):10
pubmed: 29402289
N Engl J Med. 2007 Jan 18;356(3):227-36
pubmed: 17229950
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69
pubmed: 16775176
Clin Imaging. 2017 Mar - Apr;42:119-125
pubmed: 27951458
Ann Intern Med. 2016 Oct 4;165(7):457-464
pubmed: 27428568
Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2268-74
pubmed: 18768492
Med Phys. 2010 Jan;37(1):227-33
pubmed: 20175485
Br J Cancer. 2021 Sep;125(6):884-892
pubmed: 34168297
J Magn Reson Imaging. 2015 Nov;42(5):1281-90
pubmed: 25920074
J Magn Reson Imaging. 2013 Aug;38(2):474-81
pubmed: 23292922
JAMA Oncol. 2018 Sep 1;4(9):e180174
pubmed: 29621362
J Magn Reson Imaging. 1995 Nov-Dec;5(6):695-701
pubmed: 8748488
Eur Radiol. 2015 Oct;25(10):2869-79
pubmed: 25903702