Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Case-Control Studies Endometriosis Estrogen Replacement Therapy Female Humans Hysterectomy Menopause Ovarian Neoplasms
Endometriosis Hormone therapy Hysterectomy Ovarian cancer

Journal

Gynecologic oncology
ISSN: 1095-6859
Titre abrégé: Gynecol Oncol
Pays: United States
ID NLM: 0365304

Informations de publication

Date de publication:
01 2022
Historique:
received: 23 08 2021
revised: 17 10 2021
accepted: 26 10 2021
pubmed: 16 11 2021
medline: 23 2 2022
entrez: 15 11 2021
Statut: ppublish

Résumé

To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. We conducted a pooled analysis of self-reported data from 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC). Women with (n = 5350) and without ovarian cancer (n = 7544) who never used HT or exclusively used either estrogen-only therapy (ET) or estrogen+progestin therapy (EPT) were included. Risk of invasive epithelial ovarian cancer adjusted for duration of ET and EPT use and stratified on history of endometriosis was determined using odds ratios (ORs) with 95% confidence intervals (CIs). Overall and among women without endometriosis, there was a positive association between ovarian cancer risk and hysterectomy (OR = 1.19, 95% CI 1.09-1.31 and OR = 1.20, 95% CI 1.09-1.32, respectively), but no association upon adjusting for duration of ET and EPT use (OR = 1.04, 95% CI 0.94-1.16 and OR = 1.06, 95% CI 0.95-1.18, respectively). Among women with a history of endometriosis, there was a slight inverse association between hysterectomy and ovarian cancer risk (OR = 0.93, 95% CI 0.69-1.26), but this association became stronger and statistically significant after adjusting for duration of ET and EPT use (OR = 0.69, 95% CI 0.48-0.99). The hysterectomy-ovarian cancer association is complex and cannot be understood without considering duration of ET and EPT use and history of endometriosis. Failure to take these exposures into account in prior studies casts doubt on their conclusions. Overall, hysterectomy is not risk-reducing for ovarian cancer, however the inverse association among women with endometriosis warrants further investigation.

Identifiants

DOI: 10.1016/j.ygyno.2021.10.088 PMID: 34776242 PMC: PMC9444325
pubmed: 34776242
pii: S0090-8258(21)01552-3
doi: 10.1016/j.ygyno.2021.10.088
pmc: PMC9444325
mid: NIHMS1828695
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

195-201

Subventions

Organisme : NCI NIH HHS
ID : R01 CA087538
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058860
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA080742
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA074850
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA063678
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA105009
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25524
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA115195
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054419
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA076016
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067006
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112523
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA063113
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067010
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA113148
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058598
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA017054
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN025403
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest Penelope M. Webb reports grant funding from Astra Zeneca for an unrelated study of ovarian cancer. Joellen Schildkraut and Malcolm Pike report grant funding from the National Institutes of Health. Renee Fortner reports grant funding from the German Federal Ministry of Education and Research, Programme of Clinical Biomedical Research.

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Auteurs

Lilah Khoja (L)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: lkhoja@umich.edu.

Rachel Palmieri Weber (RP)

Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27705, USA. Electronic address: rachel.weber@epividian.com.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. Electronic address: penny.webb@qimrberghofer.edu.au.

Susan J Jordan (SJ)

School of Public Health, The University of Queensland, Brisbane, Queensland 4006, Australia. Electronic address: s.jordan@uq.edu.au.

Aruna Muthukumar (A)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: arumuthu@umich.edu.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: j.chang-claude@dkfz.de.

Renée T Fortner (RT)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: r.fortner@dkfz-heidelberg.de.

Allan Jensen (A)

Department of Lifestyle, Reproduction and Cancer, Danish Cancer Society Research Center, Copenhagen, DK-2100, Denmark. Electronic address: allan@cancer.dk.

Susanne K Kjaer (SK)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, DK-2100, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, DK-2100, Denmark. Electronic address: susanne@cancer.dk.

Harvey Risch (H)

Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA. Electronic address: harvey.risch@yale.ed.

Jennifer Anne Doherty (JA)

Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: Jen.Doherty@hci.utah.edu.

Holly R Harris (HR)

Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Program in Epidemiology, Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: hharris@fredhutch.org.

Marc T Goodman (MT)

Cancer Prevention and Genetics Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: Marc.Goodman@cshs.org.

Francesmary Modugno (F)

Women's Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, PA 15213, USA; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: fm@cs.cmu.edu.

Kirsten Moysich (K)

Division of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA. Electronic address: Moysich@roswellpark.org.

Andrew Berchuck (A)

Department of Gynecologic Oncology, Duke University Medical Center, Durham, NC 277170, USA. Electronic address: berch001@mc.duke.edu.

Joellen M Schildkraut (JM)

Emory University Rollins School of Public Health, Atlanta, GA 30322, USA. Electronic address: joellen.m.schildkraut@emory.edu.

Daniel Cramer (D)

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: dcramer@bwh.harvard.edu.

Kathryn L Terry (KL)

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: kterry@bwh.harvard.edu.

Hoda Anton-Culver (H)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92617, USA. Electronic address: hantoncu@hs.uci.edu.

Argyrios Ziogas (A)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92617, USA. Electronic address: aziogas@uci.edu.

Minh Tung Phung (MT)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: phungmt@umich.edu.

Gillian E Hanley (GE)

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: gillian.hanley@vch.ca.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA. Electronic address: anna.wu@med.usc.edu.

Bhramar Mukherjee (B)

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: bhramar@umich.edu.

Karen McLean (K)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address: karenmcl@umich.edu.

Kathleen Cho (K)

Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address: kathcho@med.umich.edu.

Malcolm C Pike (MC)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: pikem@mskcc.org.

Celeste Leigh Pearce (CL)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: lpearce@umich.edu.

Alice W Lee (AW)

Department of Public Health, California State University, Fullerton, CA 92831, USA. Electronic address: alicelee@fullerton.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Maladies de l'appareil génital féminin › Endométriose › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Hormonothérapie substitutive › Oestrogénothérapie substitutive › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Hystérectomie › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Endometriosis and menopausal hormone therapy...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Endometriosis and menopausal hormone therapy...