Blood-Brain Barrier Disruption Is Not Associated With Disease Aggressiveness in Amyotrophic Lateral Sclerosis.
amyotrophic lateral sclerosis (ALS)
blood-brain barrier
disease aggressiveness
inflammation
neurodegeneration
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
01
2021
accepted:
06
10
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
16
11
2021
Statut:
epublish
Résumé
The pathogenesis of the fatal neurodegenerative condition amyotrophic lateral sclerosis (ALS) remains to be fully understood. Blood-brain barrier damage (BBBD) has been implicated as an exacerbating factor in several neurodegenerative conditions, including ALS. Therefore, this cross-sectional study used the novel D50 progression model to assess the clinical relevance of BBBD within a cohort of individuals with either ALS (
Identifiants
pubmed: 34776835
doi: 10.3389/fnins.2021.656456
pmc: PMC8586537
doi:
Types de publication
Journal Article
Langues
eng
Pagination
656456Informations de copyright
Copyright © 2021 Prell, Vlad, Gaur, Stubendorff and Grosskreutz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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