Factors Associated With the Acceleration of Patient Enrollment in Clinical Studies: A Cross-Sectional Study.

Japan clinical research clinical research coordinator clinical research support patient enrollment site visit

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2021
Historique:
received: 11 08 2021
accepted: 13 10 2021
entrez: 15 11 2021
pubmed: 16 11 2021
medline: 16 11 2021
Statut: epublish

Résumé

Under-recruitment in clinical trials is an issue worldwide. If the number of patients enrolled is lower than expected, based on the required sample size, then the reliability of the study results and their validation tend to be impaired. The current study therefore evaluated factors associated with accelerating patient enrollment using data from an ongoing multicenter prospective cohort study. The researchers encouraged research institutions to accelerate patient enrollment

Identifiants

pubmed: 34776970
doi: 10.3389/fphar.2021.753067
pii: 753067
pmc: PMC8580154
doi:

Types de publication

Journal Article

Langues

eng

Pagination

753067

Informations de copyright

Copyright © 2021 Ueda, Nishizaki, Nojiri, Iwata, Miyauchi, Matsuyama, Sanada, Minamino and Daida.

Déclaration de conflit d'intérêts

RU, YN, SN, KM, TM and SS report no conflicts of interest. HI received research grants from Mitsubishi Tanabe Pharma Corp., Kowa Pharmaceuticals Co., Ltd., and Novo Nordisc and honoraria from Bayer Yakuhin, Ltd., Daiichi Sankyo Co., Ltd., Takeda Pharmaceutical Co. Ltd., MSD KK, Kowa Pharmaceuticals Co., Ltd., and Mitsubishi Tanabe Pharma Corp. KM received honoraria from Sanofi, Daiichi-Sankyo, Bayer Health Care, Bristol Myers Squibb, and MSD. HD received grants from Canon Medical Systems Corporation, Philips Japan, Ltd., Toho Holdings Co., Ltd., Asahi Kasei Corporation, and Inter Reha Co., Ltd.; scholarship grants from Nippon Boehringer Ingelheim Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Sanofi K.K., MSD K.K., Daiichi-Sankyo Company, Limited, Pfizer Co., Ltd., Mitsubishi Tanabe Pharma Corp., Astellas Pharma Inc., Takeda Pharmaceutical Co., Ltd., Teijin Pharma Ltd., Shionogi and Co., Ltd., Actelion Pharmaceuticals Ltd., Actelion Ltd., Kowa Pharmaceutical Company Ltd., and Bayer Yakuhin, Ltd.; and lecture fees from Amgen Inc., Daiichi-Sankyo Company, Limited, Kowa Pharmaceutical Company Ltd., and MSD K.K.

Références

BMC Med Educ. 2020 Nov 13;20(1):426
pubmed: 33187497
Fam Pract. 1993 Jun;10(2):207-11
pubmed: 8359613
BJOG. 2004 Jan;111(1):3-5
pubmed: 14687044
JAMA. 1984 Nov 2;252(17):2441-6
pubmed: 6481931
J R Coll Physicians Lond. 1994 Sep-Oct;28(5):460-3
pubmed: 7807437
Health Technol Assess. 1999;3(20):1-143
pubmed: 10683591
Acad Med. 2011 Nov;86(11):1360-6
pubmed: 21952064
BMJ. 1994 Aug 13;309(6952):457-61
pubmed: 7920132
Stat Med. 2002 Oct 15;21(19):2797-805
pubmed: 12325095
J R Coll Physicians Lond. 1998 Sep-Oct;32(5):412-6
pubmed: 9819730
Health Technol Assess. 2007 Nov;11(48):iii, ix-105
pubmed: 17999843
Control Clin Trials. 1992 Dec;13(6):466-86
pubmed: 1334819
Fam Pract. 2003 Dec;20(6):675-81
pubmed: 14701891
Med Educ. 2006 Dec;40(12):1180-7
pubmed: 17118111
Trials. 2013 Jun 09;14:166
pubmed: 23758961
N Z Med J. 2003 Nov 21;116(1186):U681
pubmed: 14657964
Clin Transl Sci. 2015 Dec;8(6):647-54
pubmed: 26643413
J Gen Intern Med. 2006 Jan;21 Suppl 1:S28-34
pubmed: 16405706

Auteurs

Rieko Ueda (R)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Medical Technology Innovation Center, Juntendo University, Tokyo, Japan.
Clinical Research and Trial Center, Juntendo Hospital, Tokyo, Japan.

Yuji Nishizaki (Y)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Medical Technology Innovation Center, Juntendo University, Tokyo, Japan.
Clinical Research and Trial Center, Juntendo Hospital, Tokyo, Japan.

Shuko Nojiri (S)

Medical Technology Innovation Center, Juntendo University, Tokyo, Japan.
Clinical Research and Trial Center, Juntendo Hospital, Tokyo, Japan.

Hiroshi Iwata (H)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Katsumi Miyauchi (K)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Kotone Matsuyama (K)

Center for Strategic Research Initiative, Nippon Medical School, Tokyo, Japan.
Department of Health Policy and Management, Nippon Medical School, Tokyo, Japan.

Shoji Sanada (S)

Department of Medical Innovation, Osaka University Hospital, Osaka, Japan.
Center for Clinical Research and Innovation, Osaka City University Hospital, Osaka, Japan.

Tohru Minamino (T)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Hiroyuki Daida (H)

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Faculty of Health Science, Juntendo University, Tokyo, Japan.

Classifications MeSH