Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.
Cardiovascular diseases
Human circulatory system
Mechanobiology
Microfluidics
Organ-on-a-chip
Journal
Biophysical reviews
ISSN: 1867-2450
Titre abrégé: Biophys Rev
Pays: Germany
ID NLM: 101498573
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
22
05
2021
accepted:
22
06
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
16
11
2021
Statut:
epublish
Résumé
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
Identifiants
pubmed: 34777617
doi: 10.1007/s12551-021-00815-8
pii: 815
pmc: PMC8555051
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
769-786Informations de copyright
© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2021.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare no competing interests.
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