KDM4 Involvement in Breast Cancer and Possible Therapeutic Approaches.
JMJD2
KDM4
KDM4 inhibitors
epigenetics
histone demethylation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
07
2021
accepted:
13
10
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Breast cancer (BC) is the second leading cause of cancer death in women, although recent scientific and technological achievements have led to significant improvements in progression-free disease and overall survival of patients. Genetic mutations and epigenetic modifications play a critical role in deregulating gene expression, leading to uncontrolled cell proliferation and cancer progression. Aberrant histone modifications are one of the most frequent epigenetic mechanisms occurring in cancer. In particular, methylation and demethylation of specific lysine residues alter gene accessibility
Identifiants
pubmed: 34778065
doi: 10.3389/fonc.2021.750315
pmc: PMC8581295
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
750315Informations de copyright
Copyright © 2021 Varghese, Del Gaudio, Cobellis, Altucci and Nebbioso.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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