Unraveling the Effect of Breast Cancer Patients' Plasma on the Targeting Ability of Folic Acid-Modified Chitosan Nanoparticles.
breast cancer cells
cellular uptake
folic acid-modified chitosan nanoparticles
normal and cancer plasma
protein corona
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
06 12 2021
06 12 2021
Historique:
pubmed:
16
11
2021
medline:
15
3
2022
entrez:
15
11
2021
Statut:
ppublish
Résumé
The formation of protein corona (PC) around nanoparticles (NPs) has been reported inside biological conditions. This effect can alter delivery capacity toward the targeted tissues. Here, we synthesized folic acid-modified chitosan NPs (FA-CS NPs) using different concentrations of folic acid (5, 10, and 20%). FA-CS NPs were exposed to plasmas of breast cancer patients and healthy donors to evaluate the possibility of PC formation. We also monitored uptake efficiency in
Identifiants
pubmed: 34779630
doi: 10.1021/acs.molpharmaceut.1c00525
doi:
Substances chimiques
Chitosan
9012-76-4
Folic Acid
935E97BOY8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM