Impact of obesity on survival in COVID-19 ARDS patients receiving ECMO: results from an ambispective observational cohort.
ARDS
COVID-19
ECMO
Obesity
Prognosis
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
15 Nov 2021
15 Nov 2021
Historique:
received:
06
08
2021
accepted:
20
10
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting severe acute respiratory distress syndrome (ARDS), requiring extra-corporeal membrane oxygenation (ECMO). We designed an ambispective observational cohort study including all consecutive adult patients admitted to 5 different ICUs from a university hospital. The main objective was to identify the risk factors of severe COVID-19 ARDS patients supported by ECMO associated with 90-day survival. Between March 1st and November 30th 2020, 76 patients with severe COVID-19 ARDS were supported by ECMO. Median (interquartile range IQR) duration of mechanical ventilation (MV) prior to ECMO was of 6 (3-10) days. At ECMO initiation, patients had a median PaO In this ambispective observational cohort of COVID-19 severe ARDS supported by ECMO, obesity was an independent factor associated with improved survival at 90-day.
Sections du résumé
BACKGROUND
BACKGROUND
Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting severe acute respiratory distress syndrome (ARDS), requiring extra-corporeal membrane oxygenation (ECMO). We designed an ambispective observational cohort study including all consecutive adult patients admitted to 5 different ICUs from a university hospital. The main objective was to identify the risk factors of severe COVID-19 ARDS patients supported by ECMO associated with 90-day survival.
RESULTS
RESULTS
Between March 1st and November 30th 2020, 76 patients with severe COVID-19 ARDS were supported by ECMO. Median (interquartile range IQR) duration of mechanical ventilation (MV) prior to ECMO was of 6 (3-10) days. At ECMO initiation, patients had a median PaO
CONCLUSION
CONCLUSIONS
In this ambispective observational cohort of COVID-19 severe ARDS supported by ECMO, obesity was an independent factor associated with improved survival at 90-day.
Identifiants
pubmed: 34779944
doi: 10.1186/s13613-021-00943-0
pii: 10.1186/s13613-021-00943-0
pmc: PMC8591429
doi:
Types de publication
Journal Article
Langues
eng
Pagination
157Informations de copyright
© 2021. The Author(s).
Références
Clin Infect Dis. 2020 Jul 28;71(15):896-897
pubmed: 32271368
Crit Care. 2016 Dec 5;20(1):392
pubmed: 27919283
Lancet Respir Med. 2021 Aug;9(8):851-862
pubmed: 33887246
Intensive Care Med. 2018 Aug;44(8):1349-1351
pubmed: 29959454
Minerva Cardioangiol. 2020 Oct;68(5):368-372
pubmed: 32336080
J Cardiothorac Vasc Anesth. 2021 Jul;35(7):1999-2006
pubmed: 33573928
Intensive Care Med. 2013 Feb;39(2):275-81
pubmed: 23160769
Obesity (Silver Spring). 2020 Nov;28(11):2049-2055
pubmed: 32735706
PLoS One. 2020 Dec 15;15(12):e0243710
pubmed: 33320904
Lancet Respir Med. 2020 Nov;8(11):1121-1131
pubmed: 32798468
Arthritis Rheumatol. 2014 Sep;66(9):2613-20
pubmed: 24782338
Crit Care. 2021 Mar 1;25(1):90
pubmed: 33648538
Ann Am Thorac Soc. 2014 Jun;11(5):802-10
pubmed: 24724902
J Crit Care. 2020 Aug;58:27-28
pubmed: 32279018
Intensive Care Med. 2013 Oct;39(10):1704-13
pubmed: 23907497
Mayo Clin Proc. 2020 Jul;95(7):1445-1453
pubmed: 32622449
Aust Crit Care. 2021 Mar;34(2):167-175
pubmed: 33250401
N Engl J Med. 2018 May 24;378(21):1965-1975
pubmed: 29791822
CMAJ Open. 2021 Mar 8;9(1):E181-E188
pubmed: 33688026
Am J Respir Crit Care Med. 2014 Jun 1;189(11):1374-82
pubmed: 24693864
Intensive Care Med. 2021 Mar;47(3):344-348
pubmed: 33420797
ASAIO J. 2021 May 1;67(5):496-502
pubmed: 33902100
Lancet. 2020 Oct 10;396(10257):1071-1078
pubmed: 32987008
BMC Health Serv Res. 2006 Dec 23;6:163
pubmed: 17187683
Intensive Care Med. 2021 Jan;47(1):60-73
pubmed: 33211135
ASAIO J. 2020 Jun;66(6):588-598
pubmed: 32358232
Mol Med Rep. 2020 Jul;22(1):9-19
pubmed: 32377709
Am J Respir Crit Care Med. 2021 Jul 1;204(1):34-43
pubmed: 33823118
J Crit Care. 2021 Feb;61:221-226
pubmed: 33220575
Membranes (Basel). 2021 Feb 27;11(3):
pubmed: 33673615
Lancet Respir Med. 2021 Aug;9(8):e80-e81
pubmed: 34146489
Metabolism. 2020 Dec;113:154378
pubmed: 33002478
JAMA. 2018 Dec 4;320(21):2251-2259
pubmed: 30347031
Ann Thorac Surg. 2015 Nov;100(5):1855-60
pubmed: 26296270
Crit Care Med. 2021 Mar 1;49(3):437-448
pubmed: 33555777
Obesity (Silver Spring). 2020 Dec;28(12):2282-2289
pubmed: 32815621
Crit Care Med. 2006 Mar;34(3):738-44
pubmed: 16521268
Anesth Analg. 2020 Sep;131(3):754-761
pubmed: 31663965
BMC Med. 2014 Apr 10;12:61
pubmed: 24722122
ASAIO J. 2021 May 1;67(5):485-495
pubmed: 33657573
EClinicalMedicine. 2020 Aug;25:100449
pubmed: 32838231