Dry Eye Symptoms and Signs in US Veterans With Gulf War Illness.

Cross-Sectional Studies Dry Eye Syndromes / diagnosis Eye Pain / diagnosis Gulf War Humans Persian Gulf Syndrome / diagnosis Prospective Studies Veterans

Journal

American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500

Informations de publication

Date de publication:
05 2022
Historique:
received: 20 07 2021
revised: 06 11 2021
accepted: 08 11 2021
pubmed: 16 11 2021
medline: 26 4 2022
entrez: 15 11 2021
Statut: ppublish

Résumé

To examine dry eye (DE) symptoms and signs in individuals with vs without Gulf War illness (GWI). Prospective cross-sectional study. We performed a prospective, cross-sectional study of South Florida veterans who were active duty during the Gulf War era (GWE; 1990-1991) and seen at an eye clinic between October 1, 2020, and March 13, 2021. Veterans were split into 2 groups: those who met Kansas criteria for GWI (cases, n = 30) and those who did not (controls, n = 41). DE symptoms were assessed via standardized questionnaires whereas DE signs were assessed using a series of ocular surface parameters. Differences between groups were assessed via Mann-Whitney U test. Linear regression analyses were used to examine which GWI symptoms most closely aligned with DE symptoms. Veterans with GWI had higher DE symptoms scores compared to controls (Ocular Surface Disease Index [OSDI] scores: mean 41.20±22.92 vs 27.99±24.03, P = .01). In addition, veterans with GWI had higher eye pain scores compared with controls (average eye pain over past week: 2.63±2.72 vs 1.22±1.50, P = .03), including on neuropathic ocular pain questionnaires (Neuropathic Pain Symptom Inventory modified for the Eye [NPSI-E]: 17.33±17.20 vs 9.63±12.64, P = .03). DE signs were mostly similar between the groups. GWI symptoms "nausea or upset stomach" (β=14.58, SE = 3.02, P < .001) and "headache" (β=7.90, SE = 2.91, P = .011) correlated with higher OSDI scores. Individuals with GWI have more severe DE symptoms and ocular pain scores but similar tear and ocular surface parameters compared to controls without GWI. This finding suggests that mechanisms beyond tear dysfunction drive eye symptoms in GWI.

Identifiants

DOI: 10.1016/j.ajo.2021.11.010 PMID: 34780800 PMC: PMC9035031
pubmed: 34780800
pii: S0002-9394(21)00588-2
doi: 10.1016/j.ajo.2021.11.010
pmc: PMC9035031
mid: NIHMS1756462
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

32-40

Subventions

Organisme : BLRD VA
ID : I01 BX004893
Pays : United States
Organisme : CSRD VA
ID : I01 CX002015
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026174
Pays : United States
Organisme : NEI NIH HHS
ID : R61 EY032468
Pays : United States

Informations de copyright

Published by Elsevier Inc.

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Auteurs

Victor Sanchez (V)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Brandon S Baksh (BS)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Kimberly Cabrera (K)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Anjalee Choudhury (A)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Katherine Jensen (K)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Nancy Klimas (N)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.

Anat Galor (A)

From the New York University Grossman School of Medicine (V.S.), New York, New York; University of Miami Miller School of Medicine (B.S.B., A.C., N.K., A.G.), Miami, Florida; Ophthalmology, Miami Veterans Affairs Medical Center (K.C.), Miami, Florida; and Bascom Palmer Eye Institute, University of Miami (A.C., A.G.), Miami, Florida, USA.. Electronic address: agalor@med.miami.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › Maladies de l'oeil › Maladies de l'appareil lacrymal › Syndromes de l'oeil sec › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur oculaire › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 20ème siècle › Guerre du Golfe › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › Maladies professionnelles › Syndrome de la guerre du Golfe › Dry Eye Symptoms and Signs in US Veterans With...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Dry Eye Symptoms and Signs in US Veterans With...
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