Postnatal Maturation of Glutamatergic Inputs onto Rat Jaw-closing and Jaw-opening Motoneurons.

Animals Excitatory Postsynaptic Potentials Masseter Muscle Motor Neurons Rats Receptors, N-Methyl-D-Aspartate Synaptic Transmission
NMDA receptor feeding behavior mastication non-NMDA receptor postnatal development suckling

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 01 2022
Historique:
received: 24 06 2021
revised: 15 10 2021
accepted: 03 11 2021
pubmed: 16 11 2021
medline: 20 1 2022
entrez: 15 11 2021
Statut: ppublish

Résumé

Motoneurons that innervate the jaw-closing and jaw-opening muscles play a critical role in oro-facial behaviors, including mastication, suckling, and swallowing. These motoneurons can alter their physiological properties through the postnatal period during which feeding behavior shifts from suckling to mastication; however, the functional synaptic properties of developmental changes in these neurons remain unknown. Thus, we explored the postnatal changes in glutamatergic synaptic transmission onto the motoneurons that innervate the jaw-closing and jaw-opening musculatures during early postnatal development in rats. We measured miniature excitatory postsynaptic currents (mEPSCs) mediated by non-NMDA receptors (non-NMDA mEPSCs) and NMDA receptors in the masseter and digastric motoneurons. The amplitude, frequency, and rise time of non-NMDA mEPSCs remained unchanged among postnatal day (P)2-5, P9-12, and P14-17 age groups in masseter motoneurons, whereas the decay time dramatically decreased with age. The properties of the NMDA mEPSCs were more predominant at P2-5 masseter motoneurons, followed by reduction as neurons matured. The decay time of NMDA mEPSCs of masseter motoneurons also shortened remarkably across development. Furthermore, the proportion of NMDA/non-NMDA EPSCs induced in response to the electrical stimulation of the supratrigeminal region was quite high in P2-5 masseter motoneurons, and then decreased toward P14-17. In contrast to masseter motoneurons, digastric motoneurons showed unchanged properties in non-NMDA and NMDA EPSCs throughout postnatal development. Our results suggest that the developmental patterns of non-NMDA and NMDA receptor-mediated inputs vary among jaw-closing and jaw-opening motoneurons, possibly related to distinct roles of respective motoneurons in postnatal development of feeding behavior.

Identifiants

DOI: 10.1016/j.neuroscience.2021.11.016 PMID: 34780923
pubmed: 34780923
pii: S0306-4522(21)00575-3
doi: 10.1016/j.neuroscience.2021.11.016
pii:
doi:

Substances chimiques

Receptors, N-Methyl-D-Aspartate 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

42-55

Informations de copyright

Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no potential conflicts of interest.

Auteurs

Shiro Nakamura (S)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan. Electronic address: snaka@dent.showa-u.ac.jp.

Risa Kajiwara (R)

Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry, 2-2-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.

Tsuyoshi Noguchi (T)

Department of Special Needs Dentistry, Division of Oral Rehabilitation Medicine, Showa University School of Dentistry, 2-2-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.

Kiyomi Nakayama (K)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan.

Ayako Mochizuki (A)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan.

Masanori Dantsuji (M)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan.

Avijite Kumer Sarkar (AK)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan.

Tomio Inoue (T)

Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555 Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Système stomatognathique › Muscles masticateurs › Muscle masséter › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Postnatal Maturation of Glutamatergic Inputs...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Postnatal Maturation of Glutamatergic Inputs...