Roles of the tissue-type plasminogen activator in immune response.
Antigen-Presenting Cells
/ immunology
Blood Coagulation
/ immunology
COVID-19
/ epidemiology
Endothelial Cells
/ immunology
Fibrinolysis
/ immunology
Humans
Immunity
/ immunology
Models, Immunological
Pandemics
SARS-CoV-2
/ immunology
T-Lymphocytes
/ immunology
Tissue Plasminogen Activator
/ immunology
Antigen presenting cells
Immunopathology
Macrophages
Plasmin
Plasminogen activation system
T cells
Tissue-type plasminogen activator
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
20
08
2021
revised:
06
10
2021
accepted:
29
10
2021
pubmed:
16
11
2021
medline:
27
1
2022
entrez:
15
11
2021
Statut:
ppublish
Résumé
The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis- and receptor-mediated effects of tPA on immune response in physiological and pathological context.
Identifiants
pubmed: 34781155
pii: S0008-8749(21)00170-2
doi: 10.1016/j.cellimm.2021.104451
pmc: PMC8577548
pii:
doi:
Substances chimiques
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104451Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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