Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2.
HR2
SARS-CoV-2
adaptive mutations
antibody escape
homoplasy
spike
variants
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
pubmed:
17
11
2021
medline:
6
1
2022
entrez:
16
11
2021
Statut:
ppublish
Résumé
We have detected two mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at amino acid positions 1163 and 1167 that appeared independently in multiple transmission clusters and different genetic backgrounds. Furthermore, both mutations appeared together in a cluster of 1,627 sequences belonging to clade 20E. This cluster is characterized by 12 additional single nucleotide polymorphisms but no deletions. The available structural information on the S protein in the pre- and postfusion conformations predicts that both mutations confer rigidity, which could potentially decrease viral fitness. Accordingly, we observed reduced infectivity of this spike genotype relative to the ancestral 20E sequence
Identifiants
pubmed: 34781748
doi: 10.1128/mBio.02315-21
pmc: PMC8593680
doi:
Substances chimiques
Antibodies, Neutralizing
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0231521Subventions
Organisme : European Commission-NextGenerationEU
Organisme : Ministerio de Ciencia, Innovación y Universidades (MCIU)
ID : RTI2018-094399-A-I00
Organisme : MEC | Instituto de Salud Carlos III (ISCIII)
ID : COV20/00140
Organisme : GVA | Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana (CIUCSD)
ID : SEJI/2019/011
Organisme : MEC | Consejo Superior de Investigaciones Científicas (CSIC)
ID : CSIC-COV19-021
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