Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.
G-protein-coupled
chemokines
diabetes mellitus
inflammation
receptors
type 2
Journal
BMJ open diabetes research & care
ISSN: 2052-4897
Titre abrégé: BMJ Open Diabetes Res Care
Pays: England
ID NLM: 101641391
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
22
03
2021
accepted:
25
10
2021
entrez:
16
11
2021
pubmed:
17
11
2021
medline:
31
12
2021
Statut:
ppublish
Résumé
A potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice are complicated by non-selective deletion of We hypothesized that a High-fat feeding studies in Collectively, human and mouse data suggest that GPR21 influences both glucose homeostasis and MCP-1/CCL2-CCR2-driven monocyte migration. However, a
Identifiants
pubmed: 34782333
pii: 9/2/e002285
doi: 10.1136/bmjdrc-2021-002285
pmc: PMC8593704
pii:
doi:
Substances chimiques
CCL2 protein, human
0
CCR2 protein, human
0
Ccr2 protein, mouse
0
Chemokine CCL2
0
GPR21 protein, human
0
GPR21 protein, mouse
0
Receptors, CCR2
0
Receptors, G-Protein-Coupled
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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