Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology.

Cross-Sectional Studies Female Humans Italy / epidemiology Male Registries Rheumatology Scleroderma, Systemic / diagnosis Sex Characteristics Sjogren's Syndrome Stroke Volume Ventricular Function, Left
scleroderma sex systemic sclerosis

Journal

The Journal of rheumatology
ISSN: 0315-162X
Titre abrégé: J Rheumatol
Pays: Canada
ID NLM: 7501984

Informations de publication

Date de publication:
02 2022
Historique:
accepted: 27 10 2021
pubmed: 17 11 2021
medline: 3 5 2022
entrez: 16 11 2021
Statut: ppublish

Résumé

There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.

Identifiants

DOI: 10.3899/jrheum.210794 PMID: 34782448
pubmed: 34782448
pii: jrheum.210794
doi: 10.3899/jrheum.210794
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-185

Investigateurs

Clodoveo Ferri (C)
Marco Matucci-Cerinic (M)
Giuseppina Abignano (G)
Cecilia Agnes (C)
Giorgio Amato (G)
Alarico Ariani (A)
Gianluca Bagnato (G)
Gianluigi Bajoicchi (G)
Simone Barsotti (S)
Silvia Bellando-Randone (S)
Alessia Benenati (A)
Lorenzo Beretta (L)
Gerolamo Bianchi (G)
Silvia Bosello (S)
Fabio Cacciapaglia (F)
Francesca Calabrese (F)
Maurizio Caminiti (M)
Corrado Campochiaro (C)
Renato Carignola (R)
Ilaria Cavazzana (I)
Giovanni Ciano (G)
Veronica Codullo (V)
Franco Cozzi (F)
Cuomo Giovanna (C)
Salvatore D'Angelo (S)
Lorenzo Dagna (L)
Dall'Ara Francesca (D)
Ilenia De Andres (I)
Rossella De Angelis (R)
Angelo De Cata (A)
Giacomo De Luca (G)
Maria De Santis (M)
Alessandra Della Rossa (AD)
Andrea Doria (A)
Doveri Marica (D)
Rosario Foti (R)
Federica Furini (F)
Enrico Fusaro (E)
Elena Generali (E)
Antonietta Gigante (A)
Alessandro Giollo (A)
Francesco Girelli (F)
Dilia Giuggioli (D)
Marcello Govoni (M)
Serena Guiducci (S)
Florenzo Iannone (F)
Francesca Ingegnoli (F)
Anna Maria Iuliano (AM)
Maria Grazia Lazzaroni (MG)
Ennio Lubrano (E)
Federica Lumetti (F)
Luca Magnani (L)
Francesco Masini (F)
Gianna Mennillo (G)
Giuseppe Murdaca (G)
Giuseppa Pagano Mariano (GP)
Simone Parisi (S)
Greta Pellegrino (G)
Clara Lisa Peroni (CL)
Erika Pigatto (E)
Valeria Riccieri (V)
Anna Maria Risa (AM)
Nicoletta Romeo (N)
Edoardo Rosato (E)
Gianluca Sambataro (G)
Marta Saracco (M)
Giandomenico Sebastiani (G)
Amelia Spinella (A)
Rossella Talotta (R)
Elisa Visalli (E)
Licia Vultaggio (L)
Elisabetta Zanatta (E)
Giovanni Zanframundo (G)

Informations de copyright

© 2022 by the Journal of Rheumatology.

Auteurs

Rossella De Angelis (R)

R. De Angelis, MD, A.M. Risa, MD, Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona; r.deangelis@staff.univpm.it.
ORCID: 0000-0001-5169-3511

Dilia Giuggioli (D)

D. Giuggioli, MD, F. Lumetti, MD, A. Spinella, MD, C. Ferri, MD, Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena.

Gianluigi Bajocchi (G)

G. Bajocchi, MD, L. Magnani, MD, C. Salvarani, MD, Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia.
ORCID: 0000-0002-6430-800X

Lorenzo Dagna (L)

L. Dagna, MD, C. Campochiaro, MD, G. De Luca, MD, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan.
ORCID: 0000-0002-7428-315X

Giovanni Zanframundo (G)

G. Zanframundo, MD, V. Codullo, MD, Department of Rheumatology, Policlinico San Matteo, Pavia.
ORCID: 0000-0001-5042-1282

Rosario Foti (R)

R. Foti, MD, E. Visalli, MD, AOU Policlinico Vittorio Emanuele, Catania.

Fabio Cacciapaglia (F)

F. Cacciapaglia, MD, F. Iannone, MD, Rheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, Bari.
ORCID: 0000-0001-7479-4462

Giovanna Cuomo (G)

G. Cuomo, MD, F. Masini, MD, Luigi Vanvitelli University, Naples.
ORCID: 0000-0002-4292-3589

Alarico Ariani (A)

A. Ariani, MD, Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma.
ORCID: 0000-0003-1428-6102

Edoardo Rosato (E)

E. Rosato, MD, A. Gigante, MD, Department of Translational and Precision Medicine, Sapienza University of Rome.
ORCID: 0000-0002-7417-8093

Serena Guiducci (S)

S. Guiducci, MD, S. Bellando-Randone, MD, Department of Rheumatology, University of Florence, Florence.
ORCID: 0000-0003-2722-6475

Francesco Girelli (F)

F. Girelli, MD, Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì.

Valeria Riccieri (V)

V. Riccieri, MD, G. Pellegrino, MD, Department of Rheumatology, Sapienza University of Rome, Rome.

Elisabetta Zanatta (E)

E. Zanatta, MD, A. Doria, MD, Department of Rheumatology, University of Padua, Padova.

Silvia Bosello (S)

S. Bosello, MD, Institute of Rheumatology and Affine Sciences, Division of Rheumatology, Catholic University of the Sacred Heart, Rome.
ORCID: 0000-0002-4837-447X

Ilaria Cavazzana (I)

I. Cavazzana, MD, F. Dall'Ara, MD, M.G. Lazzaroni, MD, Department of Rheumatology, Spedali Civili di Brescia, Brescia.
ORCID: 0000-0002-2757-7120

Francesca Ingegnoli (F)

F. Ingegnoli, MD, Division of Clinical Rheumatology, ASST Pini, Dept. of Clinical Sciences & Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Research Center for Environmental Health, Università degli Studi di Milano, Milan.
ORCID: 0000-0002-6727-1273

Maria De Santis (M)

M. De Santis, MD, E.Generali, MD, Humanitas Clinical and Research Center IRCCS, Milan.
ORCID: 0000-0002-3196-1336

Giuseppe Murdaca (G)

G. Murdaca, MD, S. Martino Hospital-University of Genoa, Genoa.

Giuseppina Abignano (G)

G. Abignano, MD, G. Mennillo, MD, S. D'Angelo, MD, Department of Translational and Precision Medicine, Sapienza University of Rome.
ORCID: 0000-0002-1479-0133

Nicoletta Romeo (N)

N. Romeo, MD, S. Croce e Carle Hospital, Cuneo.

Alessandra Della Rossa (A)

A. Della Rossa, MD, S. Barsotti, MD, Department of Rheumatology, University of Pisa, Pisa.

Maurizio Caminiti (M)

M. Caminiti, MD, G. Pagano Mariano, MD, F. Calabrese, MD, Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria.

Annamaria Iuliano (A)

A. Iuliano, MD, G.D. Sebastiani, MD, Rheumatology Unit, San Camillo-Forlanini Hospital, Rome.

Giovanni Ciano (G)

G. Ciano, MD, Local Health Department, Avellino.

Lorenzo Beretta (L)

L. Beretta, MD, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan.

Gianluca Bagnato (G)

G. Bagnato, MD, Department of Clinical and Experimental Medicine, University of Messina, Messina.
ORCID: 0000-0002-7594-8520

Ennio Lubrano (E)

E. Lubrano, MD, Department of Rheumatology, University of Molise, Campobasso.
ORCID: 0000-0001-6189-5328

Ilenia De Andres (I)

I. De Andres, MD, Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione Garibaldi, Catania.

Alessandro Giollo (A)

A. Giollo, MD, Rheumatology Section, Department of Medicine, University of Verona, Verona.
ORCID: 0000-0001-9355-7673

Marta Saracco (M)

M. Saracco, MD, Rheumatology Unit, Mauriziano-Umberto I Hospital, Turin.

Cecilia Agnes (C)

C. Agnes, MD, San Lorenzo Hospital.

Federica Lumetti (F)

D. Giuggioli, MD, F. Lumetti, MD, A. Spinella, MD, C. Ferri, MD, Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena.
ORCID: 0000-0003-4671-7982

Amelia Spinella (A)

D. Giuggioli, MD, F. Lumetti, MD, A. Spinella, MD, C. Ferri, MD, Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena.

Luca Magnani (L)

G. Bajocchi, MD, L. Magnani, MD, C. Salvarani, MD, Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia.
ORCID: 0000-0002-7534-0785

Corrado Campochiaro (C)

L. Dagna, MD, C. Campochiaro, MD, G. De Luca, MD, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan.
ORCID: 0000-0001-6806-3794

Giacomo De Luca (G)

L. Dagna, MD, C. Campochiaro, MD, G. De Luca, MD, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan.
ORCID: 0000-0002-5306-7714

Veronica Codullo (V)

G. Zanframundo, MD, V. Codullo, MD, Department of Rheumatology, Policlinico San Matteo, Pavia.
ORCID: 0000-0003-2557-8514

Elisa Visalli (E)

R. Foti, MD, E. Visalli, MD, AOU Policlinico Vittorio Emanuele, Catania.
ORCID: 0000-0002-8213-5528

Francesco Masini (F)

G. Cuomo, MD, F. Masini, MD, Luigi Vanvitelli University, Naples.

Antonietta Gigante (A)

E. Rosato, MD, A. Gigante, MD, Department of Translational and Precision Medicine, Sapienza University of Rome.

Silvia Bellando-Randone (S)

S. Guiducci, MD, S. Bellando-Randone, MD, Department of Rheumatology, University of Florence, Florence.

Greta Pellegrino (G)

V. Riccieri, MD, G. Pellegrino, MD, Department of Rheumatology, Sapienza University of Rome, Rome.

Erika Pigatto (E)

E. Pigatto, MD, F. Cozzi, MD, Department of Medicine, Villa Salus Hospital, Venice.

Francesca Dall'Ara (F)

I. Cavazzana, MD, F. Dall'Ara, MD, M.G. Lazzaroni, MD, Department of Rheumatology, Spedali Civili di Brescia, Brescia.

Maria Grazia Lazzaroni (MG)

I. Cavazzana, MD, F. Dall'Ara, MD, M.G. Lazzaroni, MD, Department of Rheumatology, Spedali Civili di Brescia, Brescia.

Elena Generali (E)

M. De Santis, MD, E.Generali, MD, Humanitas Clinical and Research Center IRCCS, Milan.
ORCID: 0000-0002-5898-1767

Gianna Mennillo (G)

G. Abignano, MD, G. Mennillo, MD, S. D'Angelo, MD, Department of Translational and Precision Medicine, Sapienza University of Rome.

Simone Barsotti (S)

A. Della Rossa, MD, S. Barsotti, MD, Department of Rheumatology, University of Pisa, Pisa.
ORCID: 0000-0002-4864-4505

Giuseppa Pagano Mariano (GP)

M. Caminiti, MD, G. Pagano Mariano, MD, F. Calabrese, MD, Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria.

Francesca Calabrese (F)

M. Caminiti, MD, G. Pagano Mariano, MD, F. Calabrese, MD, Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria.

Federica Furini (F)

F. Furini, MD, L. Vultaggio, MD, M. Govoni, MD, Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara.
ORCID: 0000-0002-0295-1913

Licia Vultaggio (L)

F. Furini, MD, L. Vultaggio, MD, M. Govoni, MD, Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara.

Simone Parisi (S)

S. Parisi, MD, C.L. Peroni, MD, E. Fusaro, MD, Rheumatology Unit, Città della Salute e della Scienza, Turin.

Clara Lisa Peroni (CL)

S. Parisi, MD, C.L. Peroni, MD, E. Fusaro, MD, Rheumatology Unit, Città della Salute e della Scienza, Turin.

Anna Maria Risa (AM)

R. De Angelis, MD, A.M. Risa, MD, Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona.

Davide Rozza (D)

D.Rozza, MS, A. Zanetti, MS, G. Carrara, MS, G. Landolfi, MS, Epidemiology Unit, Italian Society for Rheumatology, Milan.

Anna Zanetti (A)

D.Rozza, MS, A. Zanetti, MS, G. Carrara, MS, G. Landolfi, MS, Epidemiology Unit, Italian Society for Rheumatology, Milan.
ORCID: 0000-0001-8408-451X

Greta Carrara (G)

D.Rozza, MS, A. Zanetti, MS, G. Carrara, MS, G. Landolfi, MS, Epidemiology Unit, Italian Society for Rheumatology, Milan.

Giampiero Landolfi (G)

D.Rozza, MS, A. Zanetti, MS, G. Carrara, MS, G. Landolfi, MS, Epidemiology Unit, Italian Society for Rheumatology, Milan.

Carlo Alberto Scirè (CA)

C.A. Scirè, MD, Epidemiology Unit, Italian Society for Rheumatology, Milan, and Rheumatology Unit, University of Ferrara-S. Anna Hospital, Ferrara.
ORCID: 0000-0001-7451-0271

Gerolamo Bianchi (G)

G. Bianchi, MD, Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust 3, La Colletta Hospital, Genoa.

Enrico Fusaro (E)

S. Parisi, MD, C.L. Peroni, MD, E. Fusaro, MD, Rheumatology Unit, Città della Salute e della Scienza, Turin.

Gian Domenico Sebastiani (GD)

A. Iuliano, MD, G.D. Sebastiani, MD, Rheumatology Unit, San Camillo-Forlanini Hospital, Rome.
ORCID: 0000-0003-2969-6649

Marcello Govoni (M)

F. Furini, MD, L. Vultaggio, MD, M. Govoni, MD, Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara.
ORCID: 0000-0003-0499-5773

Salvatore D'Angelo (S)

G. Abignano, MD, G. Mennillo, MD, S. D'Angelo, MD, Department of Translational and Precision Medicine, Sapienza University of Rome.
ORCID: 0000-0002-7442-1110

Franco Cozzi (F)

E. Pigatto, MD, F. Cozzi, MD, Department of Medicine, Villa Salus Hospital, Venice.
ORCID: 0000-0003-3627-3927

Andrea Doria (A)

E. Zanatta, MD, A. Doria, MD, Department of Rheumatology, University of Padua, Padova.
ORCID: 0000-0003-0548-4983

Florenzo Iannone (F)

F. Cacciapaglia, MD, F. Iannone, MD, Rheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, Bari.
ORCID: 0000-0003-0474-5344

Carlo Salvarani (C)

G. Bajocchi, MD, L. Magnani, MD, C. Salvarani, MD, Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia.
ORCID: 0000-0001-5426-5133

Marco Matucci-Cerinic (M)

M. Matucci-Cerinic, MD, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, and Department of Rheumatology, University of Florence, Florence, Italy.
ORCID: 0000-0002-9324-3161

Clodoveo Ferri (C)

D. Giuggioli, MD, F. Lumetti, MD, A. Spinella, MD, C. Ferri, MD, Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena.
ORCID: 0000-0002-0840-5817

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Rhumatologie › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Sclérodermie systémique › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Syndrome de Gougerot-Sjögren › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Débit cardiaque › Débit systolique › Sex-related Differences in Systemic Sclerosis:...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Fonction ventriculaire gauche › Sex-related Differences in Systemic Sclerosis:...