Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
15 11 2021
15 11 2021
Historique:
received:
10
11
2020
accepted:
27
10
2021
entrez:
16
11
2021
pubmed:
17
11
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be improved by adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese populations. Our GWAS with genotype imputations revealed that the RNF5/AGER locus including AGER rs2070600 SNP, which introduces a G82S substitution of AGER, was the most significantly associated with FEV
Identifiants
pubmed: 34782693
doi: 10.1038/s42003-021-02813-8
pii: 10.1038/s42003-021-02813-8
pmc: PMC8593164
doi:
Substances chimiques
Biomarkers
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1288Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0405203
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0105001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0105002
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0405001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP19am0101067
Informations de copyright
© 2021. The Author(s).
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