Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing.
Animals
Biomarkers
DNA Viruses
/ genetics
Disease Resistance
Disease Susceptibility
/ immunology
Genome, Viral
/ immunology
Host-Pathogen Interactions
/ immunology
Humans
I-kappa B Kinase
/ metabolism
Immune Evasion
Immune System
Immunity, Innate
Interferon Regulatory Factor-3
/ metabolism
Protein Binding
Protein Serine-Threonine Kinases
RNA Viruses
/ genetics
Receptors, Pattern Recognition
/ metabolism
Signal Transduction
TNF Receptor-Associated Factor 3
/ metabolism
Viral Proteins
/ metabolism
Virus Diseases
/ etiology
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
09
02
2021
accepted:
07
09
2021
revised:
15
06
2021
pubmed:
17
11
2021
medline:
31
3
2022
entrez:
16
11
2021
Statut:
ppublish
Résumé
A harmonized balance between positive and negative regulation of pattern recognition receptor (PRR)-initiated immune responses is required to achieve the most favorable outcome for the host. This balance is crucial because it must not only ensure activation of the first line of defense against viral infection but also prevent inappropriate immune activation, which results in autoimmune diseases. Recent studies have shown how signal transduction pathways initiated by PRRs are positively and negatively regulated by diverse modulators to maintain host immune homeostasis. However, viruses have developed strategies to subvert the host antiviral response and establish infection. Viruses have evolved numerous genes encoding immunomodulatory proteins that antagonize the host immune system. This review focuses on the current state of knowledge regarding key host factors that regulate innate immune signaling molecules upon viral infection and discusses evidence showing how specific viral proteins counteract antiviral responses via immunomodulatory strategies.
Identifiants
pubmed: 34782737
doi: 10.1038/s12276-021-00691-y
pii: 10.1038/s12276-021-00691-y
pmc: PMC8592830
doi:
Substances chimiques
Biomarkers
0
IKBKG protein, human
0
IRF3 protein, human
0
Interferon Regulatory Factor-3
0
Receptors, Pattern Recognition
0
TNF Receptor-Associated Factor 3
0
Viral Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
TBK1 protein, human
EC 2.7.11.1
I-kappa B Kinase
EC 2.7.11.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1647-1668Informations de copyright
© 2021. The Author(s).
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