Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx.
head and neck neoplasms
histocytochemistry
maxillofacial surgery
neoplasm invasiveness
neoplasm staging
oral squamous cell carcinoma of head and neck
tumor grading
Journal
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
ISSN: 1804-7521
Titre abrégé: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
Pays: Czech Republic
ID NLM: 101140142
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
07
09
2021
accepted:
26
10
2021
medline:
15
6
2023
pubmed:
17
11
2021
entrez:
16
11
2021
Statut:
ppublish
Résumé
The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker. The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group. Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-144Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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