Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study.
Detailed subphenotyping
Large population-based study
Low back pain
Modic change
Journal
Pain and therapy
ISSN: 2193-8237
Titre abrégé: Pain Ther
Pays: New Zealand
ID NLM: 101634491
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
25
08
2021
accepted:
22
10
2021
pubmed:
17
11
2021
medline:
17
11
2021
entrez:
16
11
2021
Statut:
ppublish
Résumé
To examine the association between the five types of Modic changes and low back pain (LBP) in a large population-based cohort. Of the 952 participants in the second Wakayama Spine Study, 814 (men, 246; women, 568; mean age, 63.6 years) were included in this study. Endplate changes on magnetic resonance imaging were classified according to the Modic classification system. Low back pain (LBP) was defined as continuous back pain for at least 48 h in the past month that is currently present. The prevalence of Modic changes in the lumbar region was assessed. Multivariate logistic regression analysis was conducted to determine the association between detailed subphenotype of Modic change and LBP comparing no Modic change in the lumbar spine and each level, respectively. Modic changes throughout the lumbar spine were noted in 63.5% (n = 516) of all participants, with types I, I/II, II, II/III, and III observed in 7.8% (n = 63), 10.8% (n = 88), 40.0% (n = 326), 2.1% (n = 17), and 2.7% (n = 22), respectively. Modic types I/II were associated with LBP [odds ratio (OR): 3.26; 95% confidence interval (CI) 1.9, 5.5]. Furthermore, Modic type I/II changes at L2/3 and L4/5 were significantly associated with LBP (odds ratio: 2.77; 95% CI 1.04, 7.39 at L2/3; odds ratio: 2.86; 95% CI 1.39, 5.90 at L4/5). Type I/II Modic changes in the lumbar region are significantly associated with LBP. To the best of our knowledge, this is the first large population-based study on the association between various Modic changes and LBP.
Identifiants
pubmed: 34782999
doi: 10.1007/s40122-021-00337-x
pii: 10.1007/s40122-021-00337-x
pmc: PMC8861214
doi:
Types de publication
Journal Article
Langues
eng
Pagination
57-71Informations de copyright
© 2021. The Author(s).
Références
Ann Rheum Dis. 2009 Sep;68(9):1401-6
pubmed: 18718988
Radiology. 1988 Jul;168(1):177-86
pubmed: 3289089
Eur Spine J. 2021 Apr;30(4):1011-1017
pubmed: 33037486
Spine J. 2015 Sep 1;15(9):1933-42
pubmed: 26133258
Medicine (Baltimore). 2016 May;95(22):e3495
pubmed: 27258491
J Bone Joint Surg Am. 1990 Mar;72(3):403-8
pubmed: 2312537
Med Hypotheses. 2008;70(2):361-8
pubmed: 17624684
AJNR Am J Neuroradiol. 2015 Dec;36(12):2394-9
pubmed: 26359154
Spine (Phila Pa 1976). 2006 Jul 1;31(15):1714-8
pubmed: 16816768
Spine J. 2015 Apr 1;15(4):622-8
pubmed: 25433277
Lancet. 2015 Nov 28;386(10009):2145-91
pubmed: 26321261
Biometrics. 2005 Mar;61(1):295-304
pubmed: 15737106
Eur Spine J. 2014 Sep;23(9):1856-62
pubmed: 24828957
Global Spine J. 2015 Apr;5(2):156-64
pubmed: 25844291
Osteoarthritis Cartilage. 2014 Jan;22(1):104-10
pubmed: 24239943
Spine (Phila Pa 1976). 2006 Apr 20;31(9):1026-31
pubmed: 16641780
Eur Radiol. 2004 Sep;14(9):1574-81
pubmed: 15060839
Osteoarthritis Cartilage. 2016 Oct;24(10):1753-1760
pubmed: 27143364
Spine (Phila Pa 1976). 2003 Apr 1;28(7):715-20; discussion 721
pubmed: 12671361
Lancet. 2012 Dec 15;380(9859):2163-96
pubmed: 23245607
Spine (Phila Pa 1976). 2008 Jan 1;33(1):95-103
pubmed: 18165754
Spine J. 2012 May;12(5):411-6
pubmed: 22515998
Eur Spine J. 2006 Sep;15(9):1312-9
pubmed: 16896838
AJNR Am J Neuroradiol. 2012 Sep;33(8):1519-24
pubmed: 22499847
J Bone Miner Metab. 2009;27(5):620-8
pubmed: 19568689
Skeletal Radiol. 2009 Mar;38(3):237-44
pubmed: 19096840
Spine J. 2014 Nov 1;14(11):2568-81
pubmed: 24534386
Orthop Clin North Am. 2011 Oct;42(4):513-28, viii
pubmed: 21944588
Spine J. 2020 Jul;20(7):1025-1034
pubmed: 32135303
PLoS One. 2016 Sep 20;11(9):e0160111
pubmed: 27649071
BMC Musculoskelet Disord. 2009 Jul 03;10:81
pubmed: 19575784
Scoliosis Spinal Disord. 2018 Oct 20;13:22
pubmed: 30377668
Eur Spine J. 1998;7(5):363-8
pubmed: 9840468
Eur Spine J. 2008 Oct;17(10):1300-8
pubmed: 18648860
Lancet. 1999 Aug 14;354(9178):581-5
pubmed: 10470716
J Bone Joint Surg Br. 1994 Sep;76(5):757-64
pubmed: 8083266
Mod Rheumatol. 2010 Oct;20(5):444-51
pubmed: 20467776
Br J Radiol. 1992 May;65(773):361-9
pubmed: 1535257
Acta Radiol. 2007 Sep;48(7):748-54
pubmed: 17729006
Eur Spine J. 2012 Nov;21(11):2271-9
pubmed: 22526703
Spine (Phila Pa 1976). 2007 May 1;32(10):1116-22
pubmed: 17471095
Int J Epidemiol. 2010 Aug;39(4):988-95
pubmed: 19749026
Spine (Phila Pa 1976). 2001 Sep 1;26(17):1873-8
pubmed: 11568697
Spine J. 2015 Sep 1;15(9):1919-32
pubmed: 26303178
Radiology. 1988 Jan;166(1 Pt 1):193-9
pubmed: 3336678
Spine (Phila Pa 1976). 2005 May 15;30(10):1173-80
pubmed: 15897832
Eur Spine J. 2012 Jun;21(6):1135-42
pubmed: 22249308
Eur Spine J. 2006 Mar;15 Suppl 2:S192-300
pubmed: 16550448
Spine J. 2014 Feb 1;14(2):225-33
pubmed: 24239802
Eur Spine J. 2014 Mar;23(3):493-7
pubmed: 24221918
Spine J. 2016 Jan 1;16(1):32-41
pubmed: 26456851
J Comput Assist Tomogr. 1986 Nov-Dec;10(6):917-23
pubmed: 3782560
PLoS One. 2016 Feb 03;11(2):e0147565
pubmed: 26840834