Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study.
major depression
motor vehicle collision
posttraumatic stress disorder
trauma
Journal
Depression and anxiety
ISSN: 1520-6394
Titre abrégé: Depress Anxiety
Pays: United States
ID NLM: 9708816
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
17
09
2021
received:
17
06
2021
accepted:
26
10
2021
pubmed:
17
11
2021
medline:
8
3
2022
entrez:
16
11
2021
Statut:
ppublish
Résumé
A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6-7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.
Sections du résumé
BACKGROUND
A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions.
METHODS
Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders.
RESULTS
27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6-7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders.
CONCLUSIONS
Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.
Identifiants
pubmed: 34783142
doi: 10.1002/da.23223
pmc: PMC8732322
mid: NIHMS1762304
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-70Subventions
Organisme : NIMH NIH HHS
ID : U01 MH110925
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Am J Epidemiol. 2010 Mar 1;171(5):618-23
pubmed: 20133516
Psychol Med. 2021 May;51(7):1129-1139
pubmed: 32008580
Psychol Med. 2017 Oct;47(13):2260-2274
pubmed: 28385165
Aust N Z J Psychiatry. 2021 Jul;55(7):666-677
pubmed: 33176436
J Neurol. 1995 Sep;242(9):587-92
pubmed: 8551320
Neurobiol Stress. 2021 Jan 18;14:100297
pubmed: 33553513
Child Adolesc Psychiatry Ment Health. 2009 Oct 15;3(1):33
pubmed: 19832987
Sci Rep. 2016 Jul 05;6:29281
pubmed: 27377429
J Technol Behav Sci. 2017 Mar;2(1):41-48
pubmed: 29109968
CMAJ. 2012 May 15;184(8):895-9
pubmed: 22158397
Traffic Inj Prev. 2018;19(sup2):S109-S113
pubmed: 30543458
J Affect Disord. 2010 Sep;125(1-3):279-86
pubmed: 20071032
BMC Psychiatry. 2020 Apr 28;20(1):189
pubmed: 32345257
Mol Psychiatry. 2020 Feb;25(2):283-296
pubmed: 31745239
J Clin Psychol. 2018 Sep;74(9):1457-1484
pubmed: 29543336
Depress Anxiety. 2019 Sep;36(9):790-800
pubmed: 31356709
Mol Psychiatry. 2018 Sep;23(9):1892-1899
pubmed: 28924183
BMC Emerg Med. 2020 Jun 26;20(1):52
pubmed: 32590935
Clin Psychol Rev. 2008 Jul;28(6):1009-20
pubmed: 18406027
Am J Emerg Med. 2009 Feb;27(2):182-90
pubmed: 19371526
Int J Methods Psychiatr Res. 2004;13(2):93-121
pubmed: 15297906
Injury. 2013 Nov;44(11):1413-22
pubmed: 23916902
BMC Med. 2011 Jul 26;9:90
pubmed: 21791035
J Clin Epidemiol. 2010 Nov;63(11):1179-94
pubmed: 20685078
Am J Psychiatry. 2001 Sep;158(9):1480-5
pubmed: 11532735
J Affect Disord. 2018 Aug 15;236:172-179
pubmed: 29738952
J Trauma. 1999 Sep;47(3):460-6; discussion 466-7
pubmed: 10498298
BMC Psychiatry. 2019 May 22;19(1):156
pubmed: 31117963
Psychol Med. 2010 Oct;40(10):1669-78
pubmed: 20059801
Int J Psychiatry Med. 1997;27(2):93-105
pubmed: 9565717
Pain. 2001 Nov;94(2):149-158
pubmed: 11690728
Psychol Med. 2020 Oct 29;:1-14
pubmed: 33118917
Psychol Assess. 2016 Nov;28(11):1379-1391
pubmed: 26653052
Arch Gen Psychiatry. 2008 Apr;65(4):431-7
pubmed: 18391131
Mol Psychiatry. 2021 Jul;26(7):3108-3121
pubmed: 33077855
Mhealth. 2018 Jul 02;4:22
pubmed: 30148137